Looking for high quality 2',6'-Dihydroxyacetophenone

Chemical and physical properties 

IUPAC Name: 1-(2,6-Dihydroxyphenyl)ethanone  
Molecular Weight: 152.14732 g/mol       
Molecular Formula: C8H8O3 
Molar Refractivity: 40.04 cm3 
Molar Volume: 117.8 cm3               
Density: 1.291 g/cm3                  
Boiling Point: 262.8 C at 760 mmHg       
Flash Point: 127 C
Melting Point: 156-158  C(lit.)
Index of Refraction: 1.595  
Surface Tension: 56.1 dyne/cm 
Solubility Dioxane: 50 mg/mL, clear       
Water Solubility: sparingly soluble 
Enthalpy of Vaporization: 52.08 kJ/mol     
Vapour Pressure: 0.00656 mmHg at 25 C
CAS NO: 699-83-2   
Mainly usages : It is used in organic synthesis and it is also used as pharmaceutical intermediates.

Supply information about 2',6'-Dihydroxyacetophenone

Supply information 1:

2',6'-Dihydroxyacetophenone
Updatetime:Dec 05 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:152.14,C8H8O3
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road,

Supply information 2:

Updatetime:Oct 25 2013
Purity:99% Min. Order:1/Kilogram Supply Ability:1 Month/Metric Ton
DetailDesc: ;Acetophenone series;Aromatics;Miscellaneous Reagents;Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks.
Tel:86-571-85829152
Address:1113 Modern Star, #337 Shaoxing Road, Hangzhou, China

Supply information 3:

Updatetime:Oct 17 2013
DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!
Tel:86-1383-5989052
Address:No.9, Haikou Road, Huai'an Industiral Park, Jiangsu Province, China

Supply information 4:

2',6'-Dihydroxyacetophenone
Updatetime:Dec 06 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Acetophenone,2-acetyl-;1-(2,6-Dihydroxyphenyl)ethanone;2-Acetylbenzene-1,3-diol;2-Acetylresorcinol;Ethanone,1-(2,6-dihydroxyphenyl)-;NSC615;g-Resacetophenone;2',6'-Dihydroxy Acetophenone
Tel:0086-531-58773055
Address:No.59 Gongye South RD

Supply information 5:

2,6-Dihydroxyacetophenone
Updatetime:Oct 31 2013
DetailDesc:Zhejiang Kaili Industrial Co., Ltd. is collect Science, Industrial and Trade together for a comprehensive high-tech entities. We are mainly engaged in the research, development, production and sales of APIs and pharmaceutical intermediates.
Tel:86-571-85241926
Address:Block C&D,12/F,Lantian Business Center,No.18 Moganshan Road,Hangzhou,China

Supply information 6:

2',6'-Dihydroxyacetophenone
Updatetime:Oct 06 2013
Introduction:Profile: Beijing Hengrun Weiyuan Biotechnologies, Inc. deals with research, development, manufacturing & marketing of pharmaceuticals and intermediates. 
Tel:+86-(10)-6969-6397
Address:Room A624, No.58 Liangguan Road, Fangshan District, Beijing 102000

Supply information 7: 

2,6-Dihydroxyacetophenone
Updatetime:Dec 24 2012
Purity:99.00%min Min. Order:1.00/Kilogram Supply Ability:60 Month/Metric Ton
DetailDesc: CAS 699-83-2 2,6-Dihydroxyacetophenone EINECS 211-833-6 purity 99.00%min appearance light yellow crystal Used as Pharmaceutical synthesis intermediates or other chemical synthesis
Tel:86-519-82309902
Address:New Century Building, NO. 209 East Ave, Jintan, Changzhou 213200, Jiangsu, P.R.China


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What you know about Calcitonin salmon?

Calcitonin salmon Injection, Synthetic is indicated for the treatment of symptomatic Paget's disease of bone, for the treatment of hypercalcemia, and for the treatment of postmenopausal osteoporosis.

Calcitonin salmon(CAS NO: 47931-85-1) is used to treat osteoporosis in women who are at least 5 years past menopause and cannot or do not want to take estrogen products. Osteoporosis is a disease that causes bones to weaken and break more easily. Calcitonin is a human hormone that is also found in salmon. It works by preventing bone breakdown and increasing bone density .

Some medical conditions may interact with Calcitonin salmon(CAS NO: 47931-85-1) spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances.

The hormone participates in calcium and phosphorus metabolism. In many ways, calcitonin counteracts parathyroid hormone .More specifically, calcitonin lowers blood Ca2+ levels in three ways:Inhibits Ca2+ absorption by the intestines; Inhibits osteoclast activity in bones; Inhibits renal tubular cell reabsorption of Ca2+ allowing it to be excreted in the urine.

However, effects of calcitonin that mirror those of PTH include the following:
Inhibits phosphate reabsorption by the kidney tubules.
In its skeleton-preserving actions, calcitonin protects against calcium loss from skeleton during periods of calcium mobilization, such as pregnancy and, especially, lactation.
Other effects are in preventing postprandial hypercalcemia resulting from absorption of Ca2+. Also, calcitonin inhibits food intake in rats and monkeys, and may have CNS action involving the regulation of feeding and appetite.

The panel voted 12-9 that the benefit of calcitonin salmon products in treating bone-thinning associated with osteoporosis is outweighed by a potential increase in the risk of cancer. It is a man-made version of the hormone calcitonin that is found in salmon. It products include Novartis AG's Miacalcin injection and nasal spray and Unigene Laboratories Inc's nasal spray. Privately held Upsher Smith Laboratories Inc distributes Unigene's product in the United States. Generic calcitonin products are also available.

The panel voted 20-1 that companies developing new calcitonin salmon products must prove they are effective in reducing fracture risk.The result follows an FDA staff review that found significant questions remain over whether calcitonin salmon is effective in reducing fractures.

Last July, European regulators recommended that long-term use of Calcitonin salmon be curtailed after a review found evidence of a small increased risk of cancer with long-term use of the drugs.They ruled that the benefits of Calcitonin salmon-containing medicines did not outweigh their risks in the treatment of osteoporosis and that they should no longer be used for this condition.

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Global Suppliers of 2,3-dichloro-5-(trifluoromethyl)pyridine

In this article, I will show you some suppliers information about this chemical on Guidechem, if you need to buy some 2,3-dichloro-5-(trifluoromethyl)pyridine, you can access to Guidechem, and contact them. I hope this information is useful for you.

Supplier one

2,3-Dichloro-5-trifluoromethyl pyridine(CAS NO:69045-84-7)
Updatetime:Dec 03 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

Supplier two

2,3-Dichloro-5-trifluoromethylpyridine(CAS NO:69045-84-7)
Updatetime:Oct 17 2013
DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!
Tel:86-1383-5989052
Address:No.9, Haikou Road, Huai'an Industiral Park, Jiangsu Province, China

Supplier three

2,3-Dichloro-5-(trifluoromethyl)pyridine
Updatetime:Dec 03 2013
DetailDesc: best packing , shipping and will offer you our most competitive price . keep you good quality . hope you can come back to us . welcome you inquiry to us .
Tel:86-311-67503938
Address:1-1-818 lemo building,No.18 north of Pingan street,Qiaodong district,Shiajiazhuang

Supplier four

2,3-Dichloro-5-trifluoromethylpyridine
Updatetime:Oct 31 2013
DetailDesc:Zhejiang Kaili Industrial Co., Ltd. is collect Science, Industrial and Trade together for a comprehensive high-tech entities. We are mainly engaged in the research, development, production and sales of APIs and pharmaceutical intermediates.
Tel:86-571-85241926
Address:Block C&D,12/F,Lantian Business Center,No.18 Moganshan Road,Hangzhou,China

Supplier five

2,3-Dichloro-5-(trifluoromethyl)pyridine
Updatetime:Dec 03 2013
Tel:86-311-89830448
Address:Room 37-2-2501, Yiyuan Dong Gang Jianshe Nan Stree
Introduction:Shijiazhuang Sdyano Fine Chemical Co., Ltd. is a company specializing in pharmaceutical intermediates, liquid crystal intermediates, PDLC LCD, OLED LCD, such as fine chemicals R & D, production and sales of integrated chemical enterprise modernization. Our company has three subsidiaries: R & D center, production base and sales.

Supplier six

2,3-dichloro-5-(trifluoromethyl)pyridine
Updatetime:Oct 06 2013
Tel:+86-(10)-6969-6397
Address:Room A624, No.58 Liangguan Road, Fangshan District, Beijing 102000,
Introduction:Profile: Beijing Hengrun Weiyuan Biotechnologies, Inc. deals with research, development, manufacturing & marketing of pharmaceuticals and intermediates. Our products are 1-O-methyl-2-deoxy-d-ribose,2-deoxy-d-ribose,3-hydroxy-5-methylisoxazole,cyclohexanetetramethanol, 2,6-dimethylpyridine and 4-amino-4h-1,2,4-triazole.

Supplier seven

2,3-Dichloro-5-(trifluoromethyl)pyridine
Updatetime:Sep 03 2013
Purity:≥99.5
DetailDesc:English Name:2,3-Dichloro-5-(trifluoromethyl)pyridine Molecular Weight:215.99 Chemical Structure: CAS No:69045-84-7 Technical Qualifications: Test Items Technical Qualifications Appearance Colorless transparent liquid or crystal Active ingredient content (30M capillary column GC normalization method) ≥99.5 Maximum impurity index ≤0.3
Tel:86-571-88916579
Address:NO.136 WangJiang Nan Road, Dongyang City, Zhejiang

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Possible side effects of Docusate sodium

Docusate sodium is used to make stools softer and easier to pass. It is used in symptomatic treatment of constipation, and in painful anorectal conditions such as hemorrhoids and anal fissures for people avoiding straining during bowel movements.

Docusate sodium(CAS NO:577-11-7)may be used in people who are undergoing opioid pain therapy, are opioid dependent, or on opioid replacement therapy, though prolonged use may cause irritation of the gastrointestinal tract. Data supporting its efficacy in treating chronic constipation is lacking.

Patients taking Docusate sodium(CAS NO:577-11-7)should drink plenty of water to irrigate the bowel, thereby increasing motility. Given orally, the effects are usually seen 1 to 3 days after the first dose. Given rectally, as an enema or suppository, a bowel movement usually occurs within 5 to 20 minutes.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects of Docusate sodium have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Stomach pain, diarrhea, or cramping may occur. Irritated throat (with liquid or syrup forms) may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

If your doctor has directed you to use Docusate sodium, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if this unlikely but serious side effect occurs: rectal bleeding.

A very serious allergic reaction to Docusate sodium is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US-Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada- Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

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One of the important usages of Chlorine

Chlorine is in the halogen group and is the second lightest halogen after fluorine. It is a yellow-green gas under standard conditions, where it forms diatomic molecules. It has the highest electron affinity and the third highest electronegativity of all the reactive elements; for this reason, it is a strong oxidizing agent. Free chlorine is rare on Earth, and is usually a result of direct or indirect oxidation by oxygen.

The most common compound of chlorine(CAS NO:7782-50-5), sodium chloride, has been known since ancient times; archaeologists have found evidence that rock salt was used as early as 3000 BC and brine as early as 6000 BC. Around 1630, chlorine was recognized as a gas by the Belgian chemist and physician Jan Baptist van Helmont.

Principal applications of chlorine(CAS NO:7782-50-5) are in the production of a wide range of industrial and consumer products.For example, it is used in making plastics, solvents for dry cleaning and metal degreasing, textiles, agrochemicals and pharmaceuticals, insecticides, dyestuffs, household cleaning products, but what the most important usage of Chlorine is eliminating water pollution and cleaning up our watersheds.

A recent report by the non-profit Environmental Working Group concluded that from 1996 though 2001, more than 16 million Americans consumed dangerous amounts of contaminated tap water. The report found that water supplies in and around Washington, D.C., Philadelphia and Pittsburgh in Pennsylvania, and the Bay Area in California were putting the greatest number of people at risk, although 1,100 other smaller water systems across the country also tested positive for high levels of contaminants.

Dirty water going into the treatment plant means water contaminated with chlorination byproducts coming out of your tap, The solution is to clean up our lakes, rivers and streams, not just bombard our water supplies with chlorine.

Eliminating water pollution and cleaning up our watersheds are not going to happen overnight, but alternatives to chlorination for water treatment do exist. Dr. Montague reports that several European and Canadian cities now disinfect their water supplies with ozone instead of chlorine. Currently a handful of U.S. cities do the same, most notably Las Vegas, Nevada and Santa Clara, California.

Those of us who live far from Las Vegas or Santa Clara, though, do have other options. First and foremost is filtration at the faucet. Carbon-based filters are considered the most effective at removing THMs and other toxins. The consumer information website WaterFilterRankings.com compares various water filters on the bases of price and effectiveness. The site reports that filters from Paragon, Aquasana, Kenmore, GE and Seagul remove most if not all of the chlorine, THMs and other potential contaminates in tap water.

Concerned consumers without the money to spend on home filtration, though, can just rely on good old-fashioned patience. Chlorine and related compounds will make their way out of tap water if the container is simply left uncovered in the refrigerator for 24 hours.

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1-Methylimidazole used for m-Xylenediamine Production

1-Methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colourless liquid that is used as a specialty solvent, a base, and as a precursor to some ionic liquids. It is fundamental nitrogen heterocycle and as such mimics for various nucleoside bases as well as histidine and histamine. The CAS NO of 1-Methylimidazole is 616-47-7. With the N-methyl group, this particular derivative of imidazole cannot tautomerize. It is slightly more basic than imidazole, as indicated by the pKa's of the conjugate acids of 7.0 and 7.4. Methylation also provides a significantly lower melting point, which makes 1-methylimidazole a useful solvent.

meta -Xylenediamine (MXDA) is useful as chemical inter-mediates in the plastic and polymer fields. This compound can be prepared from the hydrogenation of isophthalonitrile(IPN) in the presence of ammonia using nickel catalyst or other metallic catalysts under high temperature and pressure.

However optimum reaction conditions are crucial to produce a high grade of MXDA because of the formation of undesirable products resulting from a partial hydrogenation, a polymerization or cleavage of the product.

In order to prevent the side reactions, IPN were hydrogenated in the presence of ammonia with organic solvents. Especially the correct choice of a solvent is a critical factor to govern the catalytic activity with desirable hydrogenation.

Conven-tionally, organic materials such as aromatic hydrocarbons,aliphatic alcohols, aliphatic hydrocarbons, dimethylform-amide and dioxane were employed in this reaction. Several MXDA producing processes with the organic solvent including m-xylene, pseudocumene, mesitylene, ethylben-zene, methylpyridine(CAS NO:616-47-7), benzonitrile, m-tolunitrile, MXDA and cyanopyridine were disclosed.

However, the solvents and ammonia were vaporized under the operation conditions leading to amine cleavage with the resulting formation of methylbenzyl amines or the consumption of ammonia was still significant. Recently, some researchers reported that a high yield of MXDA was achieved using isopropanol under relatively low pressure condition; however, the consumption of ammonia was very significant.

We used 1-methylimidazole for the hydrogenation of IPN to produce MXDA. Imidazole is a heterocyclic compound of five-membered diunsaturated ring structure composed of three carbon atoms and two nitrogen atoms at nonadjacent positions. Imidazoles are barely soluble in water normally, but are dissolved in organic solvents.

Here we report the successful preparation of MXDA by hydrogenation of IPN in the presence of low ammonia concentration using 1-methylimidazole as an effective solvent. 

In conclusion, 1-methylimidazole was shown to outper- form the other organic solvents in this reaction. Moreover, amount of ammonia with using 1-methylimidazole as a solvent was lower than other processes. Thus, 1-methylimidazole is an attractive solvent in IPN hydrogenation for
the production of MXDA.

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Research on 6-Methoxyindole

The IUPAC name of 6-Methoxyindole is 6-methoxy-1H-indole. With the CAS registry number 3189-13-7, it is also named as 1H-Indole, 6-methoxy-. The product's categories are Blocks; Indoles Oxindoles; Indole / Indoline / Oxindole; Indole and Indoline; Pharmacetical; Pyrroles & Indoles; Indoles; Indole Series; Simple Indoles; Indole; Pyrroles Indoles; Building Blocks; Heterocyclic Building Blocks. Besides, it is white shiny crystals, which should be stored in closed, cool and dry place. It is light sensitive. In addition, its molecular formula is C9H9NO and molecular weight is 147.18.

Apart from theab initio predicted energy ordering, ad-ditional evidence regarding the question, if the observed statehas characteristics of an Laor Lb state, is the orientation of the TDM vector. According to the experimental findings the sign ofθis positive and hence the observed state is Lb-like. The ab initio calculations, however, predictθto be negative what would be a signature of an 1La state. We have shown recently that the orientation of the TDM in special cases extremely depends on the geometry of the electronic states involved.

This is also the case for 6-Methoxyindole(CAS NO:3189-13-7). The contributions to the La and the Lb are heavily mixed for both states which is also mir-rored by the excited state geometry of the S1. Slight geometry changes might influence the relative influence of contributions and thus have a pronounced effect on the electronic nature of the respective states. Therefore, we believe that the quite dif-ferent orientation in the ab initio calculation compared to the experiment might be a consequence of vibrational averaging of the equilibrium structure.

From the experimental point of view, the interpretation of the results is less ambiguous. A strong evidence for a pos-itive sign ofθ, and hence for the 1Lb, is the orientation of the TDM vector from the spectra of the deuterated species. In total 7 spectra were analyzed and for all of themθcould be determined with high accuracy. The correct assignment of the spectra to the respective isotopomers is based on the ro-tational constants and supported by the additivity of the zero point energy shifts and the TDM orientation. Further experi-mental results pointing towards the S1 being the 1Lb,arethe excitation energies of the lowest two excited singlet states. 

In 5-methoxyindole, the energetic gap between 1Lband 1La in-creases to 3088 cm−1 compared to indole. This is mainly due to a strong redshift of the 1Lb state, while the 1La is not influenced significantly. As shown in a number of stud-ies the energetic position of the 1La state is not perturbed much by methyl- or methoxy substituents and from linear dichroism measurements it is known that in 6-Methoxyindole the en-ergetic gap is of the same magnitude. With this in view, it is rather unlikely that changing the position of the methoxy group from 5 to 6 results in a dramatic redshift of the 1La, while the 1Lb is shifted to the same extent to higher en-ergies. Interestingly, the ab initio excitation energies are in good agreement with the experiment, in spite of the other discrepancies.

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