The cancer risk of 1,4-Dioxane

1,4-Dioxane is used as a solvent. Acute inhalation exposure to high levels of 1,4-dioxane has caused vertigo, drowsiness, headache, anorexia and irritation of the eyes, nose, throat, and lungs in humans. It may also irritate the skin. Damage to the liver and kidneys has been observed in rats chronically exposed in their drinking water.  

In three epidemiologic studies on workers exposed to 1,4-dioxane(CAS NO:123-91-1), the observed number of cancer cases did not differ from the expected cancer deaths. Tumors have been observed in orally exposed animals. EPA has classified 1,4-dioxane as a Group B2, probable human carcinogen.

1,4-Dioxane is used as a solvent for cellulose acetate, ethyl cellulose, benzyl cellulose, resins, oils, waxes, some dyes, and other organic and inorganic compounds. Some studies has proved that 1,4-Dioxane has Cancer Risk for our body.

In three epidemiologic studies on workers exposed to 1,4-dioxane, the observed number of cancer cases did not differ from the expected cancer deaths. A study by the National Cancer Institute (NCI) of rats and mice exposed to 1,4-dioxane in their drinking water reported increased incidences of liver carcinomas and adenomas and nasal cavity squamous cell carcinomas. 

Liver carcinomas and gallbladder carcinomas were observed in mice and guinea pigs, respectively. No treatment-related lesions resulted from exposure to 1,4-dioxane vapor in rats. EPA has classified 1,4-dioxane as a Group B2, probable human carcinogen. 

EPA uses mathematical models, based on human and animal studies, to estimate the probability of a person developing cancer from drinking water containing a specified concentration of a chemical. EPA calculated an oral unit risk estimate of 3.1* 10-7 ( µg/L)-1. EPA estimates that, if an individual were to continuously drink water containing 1,4-dioxane(CAS NO:123-91-1) at an average of 3.0 µg/L (3*10-3 milligrams per liter (mg/L)) over his or her entire lifetime, that person would theoretically have no more than a one-in-a-million increased chance of developing cancer as a direct result of drinking water containing 1,4-dioxane. 

Similarly, EPA estimates that drinking water containing 30.0 µg/L (3 x 10-2 mg/L) would result in not greater than a one-in-a-hundred thousand increased chance of developing cancer, and water containing 300.0 µg/L (3*10-1 mg/L) would result in not greater than a one-in-ten thousand increased chance of developing cancer. For a detailed discussion of confidence in the potency factors, please see IRIS. 

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What is 1,3-Dimethoxy benzene?

1,3-Dimethoxy benzene, which is also known as Dimethyl resorcinol, m-Dimethoxybenzene, Resorcinol dimethyl ether, Dimethylresorcinol, 3–Methoxyanisole, Dimethylether resorcinolu(Czech), 1,3-Dimethoxybenzeen, 1,3-Dimethoxybenzene and Dimethylether resorcinolu. The CAS NO of 1,3-Dimethoxy benzene is 205-783-4, MF is C8H10O2, MW is 138.1638.

The density of 1,3-Dimethoxy benzene is 1.055.  Boiling point is 85-87 ° C. Refractive index is 1.523-1.525, flash point is 87 ° C, and relative density is 1.005g/cm3.

1,3-Dimethoxy benzene is a kind of dangerous chemicals, we should know that the danger may exist in various parts of my body, and know some necessary self-help measures. Now, I will show you the Potential Health Effects and First Aid Measures of 1,3-Dimethoxy benzene.

Potential Health Effects

Eye: 1,3-Dimethoxy benzene may cause eye irritation. It may cause chemical conjunctivitis and corneal damage.

Skin: If you touch 1,3-Dimethoxy benzene accidentally, it may cause skin irritation, and may lead to cyanosis of the extremities.

Ingestion: Ingestion 1,3-Dimethoxy benzene accidentally, it may cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of 1,3-Dimethoxy benzene have not been fully investigated. It may cause respiratory tract irritation. The toxicological properties of 1,3-Dimethoxy benzene have not been fully investigated.

Inhalation: Can produce delayed pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation.

Chronic: Prolonged or repeated skin contact may cause dermatitis. Effects may be delayed. 

First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Notes to Physician: Treat symptomatically and supportively.

I hope this article can give you a little help, when you encounter 1,3-Dimethoxy benzene danger.

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