Accelerator (DM) is a white or light yellow powder with slight bitter taste, Density 1.45-1.54, soluble in chloroform, partly soluble in benzene, ethanol, carbon tetrachloride, insoluble in gasoline, water and ethyl ethanol, and stable under storing conditions. The CAS NO. is 120-78-5.
2.Application
Accelerator (DM) has medium curing rate in NR and SR; suitable for most general rubbers; Used as plasticizer and delay agent in chloroprene rubber. It is usually used together with secondary accelerator in the synthesis of polymers; has better scorch safety than MBT.
3.Biomedical Effects and Toxicity
To determine the metabolic disposition of Accelerator (DM) and Accelerator disulfide (MBTS) male and female rats were dosed topically. Topical doses were 36.1 ug/animal for Accelerator disulfide (MBTS) and 33.6 ug/animal for Accelerator (DM) .
Although more Accelerator disulfide (MBTS) passed through the skin than Accelerator (DM)and although relative to rats, guinea pigs absorbed a greater percentage of the dose (33.4% compared to 16.1-17.5% of the MBTS and 12.2% compared to 5.94-7.87% for DM) the disposition of radioactivity derived from the two compounds was similar. Washing of the skin removed more of the radioactivity from guinea pigs than from rats.
For both sexes of rats dosed iv with Accelerator disulfide (MBTS) 0.602 mg/kg) or Accelerator (DM)0.571 mg/kg) disposition of the compounds was similar. In 72 hr, 90.9-101% of the dose appeared in the urine and 3.79-15.1% in the feces. At this time a small portion of the administered radioactivity (1.52-1.96% of the dose) remained associated with erythrocytes.
Oral dosing of rats for 14 days with unlabeled MBTS (0.510 mg/kg/day) prior to a single dose of MBTS (0.503 mg/kg) or with unlabeled DM (0.521 mg/kg/day) prior to a single dose of DM(0.730 mg/kg). For both sexes disposition of the compounds was similar. At 96 hr after dosing a small portion of the administered radioactivity (1.20-1.69% of the dose) remained associated with erythrocytes most of which was bound to the membranes.
For both compounds and sexes 60.8-101% of the radioactivity administered appeared in the urine and 3.46-9.99% in the feces in 96 hr. At the time only trace amounts of radioactivity remained in tissues other than blood. Of these tissues thyroid contained the highest concentration. In the urine there was a detectable DM or MBTS but there were two metabolites one of which was identified as a thioglucuronide derivative of Accelerator disulfide (MBTS). The other was possibly a sulfonic acid derivative of Accelerator disulfide (MBTS) .
In conclusion there were similarities in absorption, distribution, and metabolism of Accelerator (DM) and Accelerator disulfide (MBTS) in rats and in guinea pigs, indicating that Accelerator (DM) was readily converted to Accelerator disulfide (MBTS).
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