Questions about Celecoxib Patients should be careful to

Topic 1: Does Celecoxib has effect on pain in my knee？

Question: doctor said:you will better after 5 month.i must take the celecoxib for 1 month.and then go to doctor again.what is my problem?will my knee better?

Answer: Celecoxib is a non-steroidal anti-inflammatory drug, which should reduce the inflammation in your knees, thereby killing the pain. Much depends on what caused the knee problem, injury, accident, twist, sprain, the list is endless. However the knee is inflamed, reason you do not say and the NSAID Celecoxib(CAS NO.: 169590-42-5) should help. 

Topic 2: Celecoxib doesn't upset the mucosal barrier in the GI tract like other NSAIDs/ibuprofen, or does it?

Question: I know that Celecoxib and ibuprofen are both NSAIDs, so therefore cox 2 inhibiting enzymes, inhibiting the production of prostaglandins thus damaging the mucosal layer in the GI tract which could lead to leaky gut syndrome and in some cases, prolong arthritis or auto immune problems. However, I was told by my doctor that Celecoxib doesn't have the same GI upset symptoms as ibuprofen. How is this so? What is the difference between them both?

Answer: In theory, the COX-2-selective medications like celecoxib have advantages over non-selective COX inhibitors like NSAIDs/ibuprofen, but studies have thus far failed to demonstrate superiority of celecoxib over ibuprofen or other NSAIDs in reducing the number of GI complications (other COX-2 inhibitors did show this, however, but they have been removed from the market due to other safety concerns; based on those findings, many still think celecoxib might provide a small GI benefit compared with nonselective NSAIDs). You do, however, avoid the platelet-inhibiting effect seen with aspirin and NSAIDs as a result of their COX-1 inhibition. Notably, the GI advantage thought of with COX-2 selective inhibitors is completely negated when combined with even low-dose aspirin. There are several circumstances where a COX-2 selective medication might be very appropriate, so obviously that determination is for you and your provider to address.

Topic 3: What are the side effects of celecoxib?

Question: I have scoliosis and was prescribed celecoxib capsules 200mg, i was wondering what the side effects are? & If i have been told to take one by the doctor will it make a differance if i took double to completely get rid of the pain?

Answer: Get emergency medical help if you have any of these signs of an allergic reaction while taking celecoxib (the active ingredient contained in Celebrex) hives; difficulty breathing; swelling of your face, lips, tongue, or throat. 

Stop using celecoxib and call your doctor at once if you have a serious side effect such as: 

1.chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance; 

2.black, bloody, or tarry stools; 

3.coughing up blood or vomit that looks like coffee grounds; 

4.swelling or rapid weight gain; 

5.urinating less than usual or not at all; 

6.nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); 

7.skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or 

8.severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. 

Less serious side effects of celecoxib may include: 

1.upset stomach, diarrhea, bloating, gas; 

2.dizziness, nervousness, headache; 

3.runny or stuffy nose, sore throat; or 

5.mild skin rash. 

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What adverse effects may Celecoxib occur？

Product name: Celecoxib

Molecular formula: C17H14F3N3O2S

Molecular Weight: 381.38

CAS NO: 169590-42-5

Celecoxib is a sulfonamide nonsteroidal antiinflammatory drug and selective COX2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer. It is known under the brand name Celebrex or Celebra for arthritis and Onsenal for polyps. Celecoxib is available by prescription in capsule form. 

Five mainly adverse effects of Celecoxib

1. Anaphylactoid reactions: Even in patients without prior exposure, anaphylactic reactions and angioedema may occur; patients with "aspirin triad" (bronchial asthma, aspirin intolerance, rhinitis) may be at increased risk. Do not use in patients who experience bronchospasm, asthma, rhinitis, or urticaria with NSAID or aspirin therapy.

2. Cardiovascular events: NSAIDs are associated with an increased risk of serious (and potentially fatal) adverse cardiovascular thrombotic events, including myocardial infarction and stroke. Risk may be increased with duration of use or pre-existing cardiovascular risk factors or disease. Carefully evaluate individual cardiovascular risk profiles prior to prescribing. New-onset hypertension or exacerbation of hypertension may occur (NSAIDs may impair response to thiazide or loop diuretics); may contribute to cardiovascular events; monitor blood pressure; use with caution in patients with hypertension. 

Celecoxib may cause sodium and fluid retention, use with caution in patients with edema or heart failure. Long-term cardiovascular risk in children has not been evaluated. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of cardiovascular events; alternate therapies should be considered for patients at high risk.

3. Gastrointestinal events: NSAIDs may increase risk of serious gastrointestinal (GI) ulceration, bleeding, and perforation (may be fatal). These events may occur at any time during therapy and without warning. Use caution with a history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, the elderly or debilitated patients. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of GI adverse events; alternate therapies should be considered for patients at high risk. When used concomitantly with ≤325 mg of aspirin, a substantial increase in the risk of gastrointestinal complications (e.g., ulcer) occurs; Concomitant gastro protective therapy (e.g., proton pump inhibitors) is recommended.

4. Hematologic effects: Anemia may occur; monitor hemoglobin or hematocrit in patients on long-term treatment. Celecoxib does not usually affect PT, PTT or platelet counts; it does not inhibit platelet aggregation at approved doses.

5. Skin reactions: NSAIDs may cause serious skin adverse events, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis; events may occur without warning and in patients without prior known sulfa allergy; discontinue use at first sign of rash (or any other hypersensitivity).

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