Let’t study something about 2,6-Dihydroxyacetophenone

Molecular Formula:C8H8O3
Molecular Weight:152.15
HS Code:29145000
Solubility:50 mg/mL in dioxane
Density:1.291 g/cm3
Boiling Point:262.8  C at 760 mmHg
Melting Point:155-158 C
Flash Point:127 C
Appearance:yellowish-beige powder
EINECS:211-833-6
CAS Registry Number:699-83-2
Stability:Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Temperature: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

2,6-Dihydroxyacetophenone(CAS NO: 699-83-2), three-necked round-bottomed flask is fitted with a reflux condenser, a dropping funnel, and a glass tube, extending to the bottom of the flask, connected to a cylinder of nitrogen. 

In the flask are placed 148 g. (0.68 mole) of 4-methyl-7-hydroxy-8-acetylcoumarin and 500 ml. of distilled water. A rapid stream of nitrogen is bubbled through the water suspension until all the air in the apparatus is displaced, and then a slow stream of the gas is kept passing through the solution. 

A solution of 129 g. (3.23 moles) of sodium hydroxide in 580 ml. of water is added through the dropping funnel, and the mixture is heated on a steam bath for 5 hours. The solution is then cooled and acidified by the addition of about 1 l. of dilute (1:3) hydrochloric acid. The stream of nitrogen gas is continued throughout the period of heating and while the solution is cooling. It may be stopped after the solution is acid. 

The crude 2,6-Dihydroxyacetophenone which separates on acidification is collected on a filter, washed three times with 50-ml. portions of cold water, and air-dried. A yield of 90-95 g. (87-92% based on the 4-methyl-7-hydroxy-8-acetylcoumarin) of light-yellow solid is obtained.

The purification is accomplished by dissolving the crude product in 1 l. of 95% ethanol, adding 20 g. of Norit, and heating the mixture on a steam cone for 15 minutes with occasional shaking. After this time, 800 ml. of warm water is added, and the solution is heated 5 more minutes and filtered through a hot funnel. 

The greenish filtrate is chilled in an ice-salt bath, and the first crop (about 65 g.) of lemon-yellow needles of 2,6-Dihydroxyacetophenone is removed by filtration. The filtrate is then concentrated under reduced pressure to a volume of 800 ml., again chilled, and the second crop of product (about 15 g.) collected on a filter. The total yield of purified 2,6-Dihydroxyacetophenone, melting at 154-155 C, is 75-85 g. (a recovery of 83–89%) .

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Buy high quality 2,4-Dichloro-5-fluoroacetophenone in Guidechem

Basic properties of 2,4-Dichloro-5-fluoroacetophenone:
Molecular Formula: C8H5Cl2FO
Molecular Weight: 207.029103
Melting point: 33-36 C  
Boiling point:167 C
Flash point: >230 F 
Appearance: White to pale-yellow Crystal
Solubility: Insoluble
EINECS: C8H5Cl2FO
CAS Registry Number: 704-10-9

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Prpduct name:2,4-Dichloro-5-fluoroacetophenone
Updatetime:Nov 20 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Acetophenone,2',4'-dichloro-5'-fluoro-(7CI,8CI); 2',4'-Dichloro-5'-fluoroacetophenone
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Prpduct name:2',4'-Dichloro-5'-fluoroacetophenone
Updatetime:Nov 19 2013
Purity:98% Min. Order:1/Gram Supply Ability:10 Month/Kilogram
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Prpduct name:2,4-Dichloro-5-fluoroacetophenone
Updatetime:Nov 19 2013
DetailDesc: CBNumber: CB6118080 Chemical Name: 2,4-dichloro-5-fluoroacetophenone Molecular Formula: C8H5Cl2FO Formula Weight: 207.03 CAS No.: 704-10-9 MOL File: Mol file
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Updatetime:Oct 31 2013
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Address:Block C&D,12/F,Lantian Business Center,No.18 Moganshan Road,Hangzhou,China

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Prpduct name:2,4-Dichloro-5-fluoroacetophenone
Updatetime:Sep 03 2013
Tel:86-574-87260209 87348868
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Introduction:Ningbo Dekang Biochem Co., Ltdmain products : plant extracts and Raw Material,Natural herbs, Herbal Supplements,Spices,Vitamins, Botanicals,Multi-herb formulas Extract,powder, granules, minced, chopped, slice ,Fruit & Vegetable Powder,Drug preparation Granules,Tablets,Capsules, Oral Suspension. We can provide the services including Assisting foreign customer’s procurement in China.


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Prpduct name:2,4-Dichloro-5-Fluoro Acetophenone
Updatetime:Jan 16 2013
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Introduction:Goly Chemical Co., Ltd. specializes in Active Pharmaceutical Ingredients, Intermediates, Specialty Chemicals, and Water Treatment Agents & Food Additives. We focus on the Special Chemicals and Fine Chemicals such as Active Pharmaceutical Ingredients Organic Intermediates Inorganic Compound Amino Acid Series Fluoro-Compound.

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