4 important information about 3-fluoropyridine

1.Identification

Product Name: 3-Fluoropyridine

Synonyms:Pyridine, 3-fluoro-

Formula:C5H4FN

Molecular Weight:97.09

Beilstein/Gmelin:105702

Beilstein Reference:5-20-05-00399

EINECS:206-755-4

CAS NO: 372-47-4

Appearance:Clear yellow liquid.

Soluble:Solubility in water

Boiling Point:107

2.First Aid Measures 3-fluoropyridine(CAS NO: 372-47-4)

Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

3.Fire Fighting Measures about 

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Suitable extinguishing media: 

For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.

Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), Hydrogen fluoride

Precautions for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary. 

Further information: Use water spray to cool unopened containers.

4.Handling and Storage

Storage:

Keep 3-fluoropyridine away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store 3-fluoropyridine in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Handling:

Wash thoroughly after handling 3-fluoropyridine. Ground and bond containers when transferring 3-fluoropyridine. Use spark-proof tools and explosion proof equipment. Avoid 3-fluoropyridine contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid 3-fluoropyridine contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

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The properties of 3-fluoropyridine

3-fluoropyridine, also called azabenzene and azine, is a heterocyclic aromatic tertiary amine characterized by a six-membered ring structure composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring (C5H5N). The CAS NO. is 372-47-4, EINECS NO. is 206-755-4, FORMULA is C5H4FN, MOL WT. is 97.09. 

The simplest member of the pyridine family is 3-fluoropyridine itself. It is colorless, flammable, toxic liquid with a unpleasant odor, miscible with water and with most organic solvents, boils at 115 C. Its aqueous solution is slightly alkaline. Its conjugate acid is called pyridinium cation, C5H5NH+, used as a oxidation agent for organic synthesis.

 3-fluoropyridine is a base with chemical properties similar to tertiary amines. Nitrogen in the ring system has an equatorial lone pair of electrons, that does not participate in the aromatic pi-bond. Its aqueous solution is slightly alkaline. It is incompatible and reactive with strong oxidizers and strong acids, and reacts violently with chlorosulfonic acid, maleic anhydride, oleum, perchromates, b-propiolactone, formamide, chromium trioxide, and sulfuric acid. 

Liquid 3-fluoropyridine(CAS NO:372-47-4) easily evaporates into the air. If it is released to the air, it may take several months to years until it breaks down into other compounds. Usually, 3-fluoropyridine is derived from coal tar or synthesized from other chemicals, mainly acetaldehyde and ammonia. 3-fluoropyridine compounds are found in nature. 

For example, nicotine from tobacco, ricinine from castor bean, pyridoxine or vitamin B and P products, alkaloids (such as coniine, piperine and nicotine), and etc. Some 3-fluoropyridine compounds consumed largely are:

Picoline : Three structural isomers of methyl 3-fluoropyridines (alpha, beta, gamma- positions)
Lutidine : Six structural isomers of dimethyl 3-fluoropyridines (2,3-, ,24-, 2,5-, 2,6-, 3,4-, 3,5- positions)
Collidine : Three structural isomers of trimethyl 3-fluoropyridines (2,3,5-, 2,3,6-, 2,4,6- positions)
Pyrimidine: 3-fluoropyridine alteration containing nitrogen atoms at positions 1 and 3
Piperidine: Hexahydro3-fluoropyridine (saturated form)
Nicotinic acid: 3-fluoropyridine-3-carboxylic acid

3-fluoropyridine and its derivatives are very important in industrial field as well as in bio chemistry. Nucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). Three major pyrimidines in living systems are cytosine, thymine, and uracil. Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. 

Some 3-fluoropyridine system is active in the metabolism in the body. Certain nitrogenous plant products also have 3-fluoropyridine class compounds. They can be the parent compound of many drugs, including the barbiturates. 3-fluoropyridine and its derivatives are used as solvents and starting material for the synthesis of target compounds such as insecticides, herbicides, medicines, vitamins, food flavorings, feed additives, dyes, rubber chemicals, explosives, disinfectants, and adhesives. 3-fluoropyridine is also used as a denaturant for antifreeze mixtures, as a dyeing assistant in textiles and in fungicides.

3-fluoropyridine is used as an intermediate for manufacturing synthetic organic, pharmaceuticals (antihistamine drug, pheniramine, the antiarrhythmic, disopyramide) and agrochemicals (fungicides, herbicides).

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