2013年12月12日星期四
New study on Mancozeb
Mancozeb is non-systemic fungicide, Organic-Dithiocarbamate group. Foliar protection of many fruits, vegetables, nuts and field crops against a wide spectrum of fungal diseases including potato blight, leaf spots, scab on apples and pears, anthracnose and rust.
For seed treatment of rice, cotton, potatoes,safflower, sorghum, peanuts, tomatoes, flax, and cereal grains.Mancozeb(CAS NO:8018-01-7) does not induce in fungi and is therefore an essential componentof alternating spray program or of mixed formulations with systemic and other fungicides.
Polyvalence: use on more than 70 crops for the control of 400 fungal diseases of which mildews, excoriosis, black-rot, red fire, alternaria, etc. Multi-site action: making it an ideal partner for recent mono-site molecules.
Nutrient: correction of crop deficiencies in manganese and zinc.The worldwide use mancozeb(CAS NO:8018-01-7) without danger to the environment. Because mancozeb break down rapidly in the environment. It is not harmful to beneficial insects and natural pollinators. Hence it is a useful product in integrated pest management programs. Mancozeb is a contact fungicide which remains on the treated surface of the plant.
Mancozeb is a member of the ethylene bisdithiocarbamate (EBDC) group of fungicides that also includes the related active ingredient metiram, the only other registered EBDC. A third EBDC, maneb, is no longer registered for use.
Mancozeb and metiram are metabolized to ethylenethiourea (ETU) in the body and both degrade to ETU in the environment. Therefore, EPA has considered the aggregate or combined risks from food, water and non-occupational exposure resulting from mancozeb alone and ETU from all sources (i.e., the other EBDC fungicides) for this action. EPA's assessment of exposures and risks associated with mancozeb and ETU follows.
Mancozeb is not acutely toxic via the oral, dermal or inhalation routes of exposure. Further, mancozeb is not a skin irritant nor is it a skin sensitizer, although it does cause mild eye irritation. The findings in multiple studies demonstrate that the thyroid is a target organ for mancozeb.
Thyroid toxicity is manifested as alternations in thyroid hormones, increased thyroid weight, and microscopic thyroid lesions (mainly thyroid follicular cell hyperplasia). These effects are due to the ETU metabolite.
Mancozeb is rapidly absorbed and eliminated in the urine. In oral rat metabolism studies with radiolabeled mancozeb and other EBDCs, an average 7.5%in vivo metabolic conversion of EBDC to ETU occurred, on a weight-to-weight basis.
Metabolism data indicate mancozeb does not bio-accumulate. Mancozeb has been tested in a series of in vitro and in vivo genotoxicity assays, which have shown that it exhibits weak genotoxic potential.
Want to learn more information about Mancozeb, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
2013年11月21日星期四
Mancozeb has bad effects on our life and environment
Mancozeb is a multi-site inhibitor affecting various enzymes and other metabolic processes in fungi. It inhibits spore germination, and is toxic to fungal cell membranes. The Molecular Formula is C4H6MnN2S4, Molecular Weight is 541.074729, and the CAS NO is 8018-01-7.
Mancozeb is mainly used for field crops, fruits, vegetables, nuts, and commercial sod farms. Seed treatment for cereal grains, corn, cotton, flax, peanuts, potatoes, safflower, sorghum, and tomatoes.Trimastan for potato blight and Cercospera of sugar beets and celery. Fore for flowers, ornamental trees, shrubs, turf sod, and golf courses. Electis, Gavel and Roxam Combi for use on grapevines. Aderio, Valbon for use on potatoes.
Mancozeb(CAS NO:8018-01-7) is marketed by the trade names Dithane, Manzeb, Nemispot, and Manzane. It is used to protect many fruit, nut, and field crops from a wide spectrum of fungal diseases.The active ingredient, mancozeb, is a fungicide in a subclass of carbamate pesticides called dithiocarbamates. They have a similar action to carbamate insecticides except they affect the nervous system through their main metabolite, carbon disulfide.
Although Mancozeb is an important drug in farm, it has some bad effects on the environment and our health.
Toxicity to Humans
Mancozeb is a cholinesterase inhibitor and can therefore have affects to the nervous system. Symptoms of exposure include fatigue, headache, blurred vision, and nausea. At high doses exposed persons can have convulsions, slurred speech, confusion, and slowed heartbeat. In lower doses, mancozeb can also cause a skin rash if the chemical has contact with the skin. In one study, a vineyard worker developed a rash on the forearm as well as inflammation of the eyelids after handling seedlings which had been treated with mancozeb.
A major toxicological concern with respect to mancozeb and other dithiocarbamates is its primary metabolite, ethylenethiourea (ETU), shown to cause thyroid and carcinogenic effects in test animals. Mancozeb is listed as a chemical known by the State of California to cause cancer in humans. Many studies dating back to 1980 show that mancozeb can cross the placental barrier and induce or increase tumor incidence. A recent study shows that mancozeb and its metabolites are capable of crossing the placental barrier and can produce DNA damage and initiate tumors in fetal cells.
Risks to the Environment
Mancozeb, if applied to soil, will have a low mobility based on its high adsorption coefficient. If it is released into water, it will tend to adsorb to sediment and suspended solids. It has low soil persistence with a reported half-life of 1-7 days. Again, the primary concern with mancozeb is its spontaneous degradation to ethylenethiourea (ETU) in the presence of water and oxygen. ETU has a persistence of 5-10 weeks. While mancozeb is practically insoluble in water making it unlikely to contaminate groundwater, its metabolite, ETU, has the potential to be mobile in soils.
Want to learn more information about Mancozeb, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
Mancozeb is mainly used for field crops, fruits, vegetables, nuts, and commercial sod farms. Seed treatment for cereal grains, corn, cotton, flax, peanuts, potatoes, safflower, sorghum, and tomatoes.Trimastan for potato blight and Cercospera of sugar beets and celery. Fore for flowers, ornamental trees, shrubs, turf sod, and golf courses. Electis, Gavel and Roxam Combi for use on grapevines. Aderio, Valbon for use on potatoes.
Mancozeb(CAS NO:8018-01-7) is marketed by the trade names Dithane, Manzeb, Nemispot, and Manzane. It is used to protect many fruit, nut, and field crops from a wide spectrum of fungal diseases.The active ingredient, mancozeb, is a fungicide in a subclass of carbamate pesticides called dithiocarbamates. They have a similar action to carbamate insecticides except they affect the nervous system through their main metabolite, carbon disulfide.
Although Mancozeb is an important drug in farm, it has some bad effects on the environment and our health.
Toxicity to Humans
Mancozeb is a cholinesterase inhibitor and can therefore have affects to the nervous system. Symptoms of exposure include fatigue, headache, blurred vision, and nausea. At high doses exposed persons can have convulsions, slurred speech, confusion, and slowed heartbeat. In lower doses, mancozeb can also cause a skin rash if the chemical has contact with the skin. In one study, a vineyard worker developed a rash on the forearm as well as inflammation of the eyelids after handling seedlings which had been treated with mancozeb.
A major toxicological concern with respect to mancozeb and other dithiocarbamates is its primary metabolite, ethylenethiourea (ETU), shown to cause thyroid and carcinogenic effects in test animals. Mancozeb is listed as a chemical known by the State of California to cause cancer in humans. Many studies dating back to 1980 show that mancozeb can cross the placental barrier and induce or increase tumor incidence. A recent study shows that mancozeb and its metabolites are capable of crossing the placental barrier and can produce DNA damage and initiate tumors in fetal cells.
Risks to the Environment
Mancozeb, if applied to soil, will have a low mobility based on its high adsorption coefficient. If it is released into water, it will tend to adsorb to sediment and suspended solids. It has low soil persistence with a reported half-life of 1-7 days. Again, the primary concern with mancozeb is its spontaneous degradation to ethylenethiourea (ETU) in the presence of water and oxygen. ETU has a persistence of 5-10 weeks. While mancozeb is practically insoluble in water making it unlikely to contaminate groundwater, its metabolite, ETU, has the potential to be mobile in soils.
Want to learn more information about Mancozeb, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.
订阅：
博文 (Atom)