Make Astragaloside IV business online

In this article, I will show you a online supply platform where you can buy or sell Astragaloside IV or any other chemicals. Here are the nearly suppliers’ informetion about Astragaloside IV (CAS NO: 84687-43-4)in guidechem.

1.shijiazhuang oufuxin import & export co. , ltd
Updatetime:Dec 26 2013
Purity:99.8%
DetailDesc: extraction method：Dynamic continuous flooding extraction, ultrasonic extraction, multi-function extraction, supercritical fluid extraction. Separation of removing impurity:Centrifugal removing impurity, membrane filtration, chromatography ingenious combination of resin purification methods, short-range molecular distillation. dry method...
Tel:86-311-69010560
Address:Shijiazhuang QiaoDongOu minsheng road 33

Shanghai Dell Chemical Co.Ltd
Astragaloside IV(CAS NO: 84687-43-4)
Updatetime:Dec 26 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

3.AFINE CHEMICALS LIMITED
Updatetime:Dec 26 2013
Min. Order:1/Gram Supply Ability:10 Month/Metric Ton
DetailDesc:Astragaloside
Tel:86-571-85232161
Address:6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China

4.Hangzhou Dayangchem Co., Ltd.
Updatetime:Dec 26 2013
DetailDesc:Astragaloside IV
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

5.Atomax Chemicals Co.,Ltd
Updatetime:Dec 11 2013
Purity:95+% Supply Ability:g/kg 
DetailDesc:Atomax Chemicals Co.,Ltd a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. we are a registered chemicals provider for most giant pharmaceutical company like Merck, Pfizer, Novartis, Roche, Astrazeneca, Sanofi-Aventis, etc.
Tel:86-755-33239182
Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

6.Shanxi Sinuote Bio-Tech Co.,Ltd
Updatetime:Dec 26 2013
Purity:Astragalus Root P.E.CAS: 84687-43-4
DetailDesc: Astragalus Root P.E. CAS: 84687-43-4 0.3%, 10%, 90%, 98% test by HPLC CAS No: 84687-43-4 Molecular Formula: C41H68O14 Molecular Mass: 784.98 2. Polysaccharides 50%, 60%, 70% astragaloside iv Astragalus Root Extract Appearance: Yellow-brown powder Tel:86-29-82507780
Address:Taiyuan Road ,Xi'an City ,China

7.Andexin industrial Co.,Limited
Updatetime:Dec 26 2013
Min. Order:1/Gram Supply Ability:10 Month/Metric Ton
DetailDesc:Astragaloside
Tel:86-411-39074598
Address:No.98,Shengli road,,Jinzhou district,

8.Changsheng International Chemical Industry Co.Ltd.
Updatetime:Dec 26 2013
Supply Ability:Success 
DetailDesc:Astragaloside IV
Tel:86-311-80955068
Address:No 98 Gongnong Street,Shijiazhuang Hebei,China

9.Boc Sciences
Astragaloside IV
Updatetime:Dec 20 2013
DetailDesc:Astragaloside IV
Tel:1-631-5046093
Address:45-16 Ramsey Road Shirley, NY 11967, USA

10.Springautumn Biological Engineering Co., Ltd.
AstragalosideIV
Updatetime:Dec 20 2013
Purity:98%
DetailDesc: Synonyms AstragalosideIV CAS RN 84687-43-4 Formula C41H68O14 Molecular Weight 784.97  Tel:86-25-84430028
Address:Room 805, No. 2, sheng li cun Road, Xuanwu District, Nanjing(Xiao-Wei Street, Nanjing Jinling biomedical science and technology industrial park)

11.chengdu king-tiger pharm-chem tech co ltd
Astragaloside IV 98%
Updatetime:Oct 24 2013
Tel:86-28-85317716
Address:No. 88 keyuan South Keyuan Road Tianfu Life Science Park C1-807

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The effects of Astragaloside IV

Ischemic heart disease is among the top causes of death in the world . PCI has currently been applied widely to deal with acute coronary syndrome, myocardial infarction and stable angina. Although PCI can restore  the blood flow in  myocardium rapidly, it does  not  reduce the risk of serious heart events because of reperfusion injury . Thus, strategy  to prevent reperfusion injury and improve PCI outcome is currently appealing in clinic.   

Here are some part of conclusions about Astragaloside IV ,it may give some suggestions to protect heart from ischemia and reperfusion injury via energy regulation mechanism.

Effect of Astragaloside IV on myocardial infarct size 

The effect of Astragaloside IV(CAS NO:84687-43-4) on myocardial infarct size at different doses was determined by Evans blue-TTC staining. As showing in the Figure 2A, the pink area represents ischemic myocardial tissue, the white area represents the infarction region, and the blue area represents normal myocardial tissue. We found that Astragaloside IV was effective  at the dose of 10 mg/kg,  and thus chose this dose for all the experiments below. The representative heart slices in I-30 min and I/R-90 min groups are shown in Figure 3A and Figure 3D, respectively. Obviously, myocardial tissue slices from I-30 min group exhibited ischemia but no infarct. 

By contrast, noticeable ischemia and infarct areas were observed in myocardial tissue slices in I/R-90 min group. As compared to I/R-90 min group, pretreatment with Astragaloside IV significantly decreased the I/R-90 min induced myocardial infarct size, but retained a similar area of ischemic region. As shown in Fig.3.B-C, E-F, quantitative analysis of AAR/ LV and infarct area/AAR confirmed the above results.   

Effect of Astragaloside IV on MBF 

Figure 4A shows the color images acquired by the Laser Scanning Doppler in the four groups at different time point. A prominent decrease in MBF occurred from 30 min after ischemia, and persisted till 90 min after reperfusion in I/R-group. Astragaloside IV pretreatment prevented MBF from decrease at 30 min ischemia, and this protective role remained by I/R-90 min. Figure 4B is the quantitative evaluation of MBF changes in the four groups, which confirmed the impression from Figure 4A.  

Effect of Astragaloside IV on heart function 

Heart function was assessed in different conditions to evaluate the role of Astragaloside IV in protecting heart against ischemia and reperfusion injury. As noticed in Fig.5, in comparison with Sham group, ischemia 30 min caused a significant decline in +dp/dtmax, and an apparent elevation in LVDP, LVEDP and -dp/dtmax, indicating an impairment on heart function. Reperfusion for 90 min led to a further decline in +dp/dtmax as well as a significant decrease in LVSP, and a sustained increase in -dp/dtmax, but did not deteriorate LVDP and LVEDP. The protective role of Astragaloside IV pretreatment for LVDP and LVEDP exhibited already at 30 min ischemia, but only at 90 min reperfusion for other parameters examined. No significant change was observed in heart rate in any group over the observation, nor among the groups at any time point (Fig.5A).  

In conclusion, Astragaloside IV pretreatment protected against myocardium injury and cardiac malfunction after I/R, which may be related to its potential to restore the  energy  metabolism disorder occurred in ischemia phase. The results provide support for Astragaloside IV as a novel therapeutic approach to protect against I/R-induc ed myocardial injury. In addition, the results of present study opened an avenue for development of new drug to cope with cardiac I/R injury by targeting energy metabolism.

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