What is Gemcitabine hydrochloride

Gemcitabine hydrochloride profile

Gemcitabine hydrochloride is used in combination with other chemotherapy drugs to treat cancer of the ovaries (cancer that begins in the female reproductive organs where eggs are formed) and breast cancer that has not improved or that has worsened after treatment with other medications.

Gemcitabine hydrochloride (CAS NO: 122111-03-9) is used in combination with other chemotherapy drugs to treat a type of lung cancer (non-small cell lung cancer; NSCLC) that has spread to other parts of the body and cannot be treated with surgery. Gemcitabine hydrochloride is also used to treat cancer of the pancreas that has spread to other parts of the body and has not improved or worsened after treatment with another medication. Gemcitabine hydrochloride is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

Basic usages of Gemcitabine hydrochloride

Gemcitabine hydrochloride comes as a powder to be mixed with liquid to be injected over 30 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. When Gemcitabine hydrochloride is used to treat ovarian or breast cancer, it is usually given on certain days every 3 weeks. When Gemcitabine hydrochloride is used to treat lung cancer it is usually given on certain days every 3 or 4 weeks. When Gemcitabine hydrochloride is used to treat cancer of pancreas it may be injected once every week. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have. Your doctor may need to stop or delay your treatment if you experience certain side effects.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other usages of Gemcitabinehydrochloride

Gemcitabine hydrochloride is also sometimes used to treat bladder cancer and cancer of the biliary tract (cancer in the organs and ducts that make and store bile, the liquid made by the liver). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving Gemcitabine hydrochloride

1) Tell your doctor and pharmacist if you are allergic to Gemcitabine hydrochloride, any other medications, or any of the ingredients in Gemcitabine hydrochloride. Ask your pharmacist for a list of the ingredients.

2) Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

3) Tell your doctor if you drink or have ever drunk large amounts of alcohol or if you have or ever had liver disease, including hepatitis, or kidney disease.

4) Tell your doctor if you have previously received or are currently receiving radiation therapy.

5) Tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while receiving Gemcitabine hydrochloride, call your doctor. Gemcitabine hydrochloride may harm the fetus.

6) Tell your doctor if you are breast-feeding. You should not breast-feed while you are receiving Gemcitabine hydrochloride injection.

Want to learn more information about Gemcitabine hydrochloride, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.

Gemcitabine hydrochloride is an anticancer drug

The name of the drug: Gemcitabine Hydrochloride for Injection

The main components of the drugs: This product mainly consists of gemcitabine hydrochloride.

Traits of Gemcitabine hydrochloride: This product is a white loose block.

CAS NO of Gemcitabine　Hydrochloride :  122111-03-9

Pharmacological action of Gemcitabine Hydrochloride: Gemcitabine hydrochloride is a nucleoside analogues, belongs to the cell cycle specific antitumor drugs. The main killer in S phase (DNA synthesis) cells, at the same time also blocked cell proliferation by G1 to S transition process. This product is superseded by intracellular nucleoside kinase metabolism into 2-nucleoside phosphate activity (dFdCDP) and 3- nucleotide (dFdCTP).

The cytotoxic activity was derived from the two kinds of nucleoside combined effect of DNA synthesis inhibition. Resulting DNA (including dCTP) reduced the concentration of gemcitabine, three phosphate can compete with dCTP binding to DNA, while the dCTP concentration in the cells decreased (generated by the role of phosphate) combined with gemcitabine can promote three phosphoric acid and DNA, the result of a nucleotide incorporation into the synthesis process DNA chain, so as to prevent further synthesis of DNA. In addition, DNA polymerase epsilon is not able to clear the gemcitabine nucleotides and repair synthesis process of the DNA chain.

Adaption of Gemcitabine Hydrochloride:  Suitable for the treatment of advanced non small cell lung cancer.

Usage and dosage of GemcitabineHydrochloride: Recommended adult dose of gemcitabine for 30 minutes 1000mg/m2 intravenous drip, once a week, for three weeks, then rest a week, each around again.

On the basis of toxicity reaction of patients decreased dose. Preparation method: bottle (including gemcitabine 200mg) at least 0.9% injection of sodium chloride injection 5ml (including the concentration of gemcitabine ≤ 40mg/ml), and shake to dissolve, when administered to the required quantity available in 0.9% sodium chloride injection further dilution, preparing gemcitabine solution good should be stored in room temperature and used within 24 hours, gemcitabine solution may not be refrigerated, to prevent crystallization.

Elderly patients: elderly patients aged 65 years and above can also very good tolerance. Despite the influence of age clearance and half-life of gemcitabine, but there is no evidence that elderly patients require dose adjustment. Children: not studied the use of gemcitabine in children.

Medication for pregnant and lactation: The B3 class, the drugs on the safety of pregnant women is unknown. The animal experiment showed that, the drug has reproductive toxicity, such as reproductive defects or the development of the embryo and fetus, before and after pregnancy and childbirth and other toxic effect. Gemcitabine has potential risk to the fetus and infant, therefore, pregnant and lactating women should avoid the use it.

Frankie is the freelance writer for e-commerce website in the chemistry. Guidechem.com is just a place for you to look for some chemicals. Our guidechemprovide the most convenient conditions for the international buyers and let these leads benefit all the business people. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.