What should be careful about Tacrolimus overdose

Tacrolimus lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader. 

Tacrolimus is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant. It may also be used for purposes not listed in this medication guide. But it is possible for someone to use too much tacrolimus(CAS NO:104987-11-3). The overdose effects will vary, based on certain factors. Possible symptoms include hives, tremors, and kidney problems. Treatment will typically involve supportive care to treat any symptoms that occur as a result of the overdose, in addition to pumping the stomach.

Treatment for a Tacrolimus Overdose

The treatment for an overdose of tacrolimus may vary. If the overdose was recent and taken by mouth, a healthcare provider may "pump the stomach" to help reduce the amount of the drug absorbed into the bloodstream. Dialysis is not expected to be helpful for removing tacrolimus from the bloodstream.

Treatment will also include supportive care, which consists of treating the symptoms that occur as a result of the overdose. For example, supportive treatment for a tacrolimus overdose may include:

Fluids through an intravenous line (IV), if necessary
Close monitoring of kidney function, body salts (electrolytes), and blood pressure
Medications to treat high blood pressure, if needed.

It is important that you seek medical attention immediately if you believe that you or someone else may have overdosed on this medication.

Effects of an Overdose

There have been reports of overdoses of up to 30 times the recommended tacrolimus dose. Based on these cases, possible overdose symptoms may include but are not limited to:
Tremors
Kidney problems
High blood pressure (hypertension)
Swelling (edema) of the arms, hands, legs, ankles, or feet
Hives
Loss of energy.

These symptoms are unlikely to occur from a tacrolimus ointment overdose, however, as very little of the medicine is absorbed through the skin into the bloodstream. Using too much tacrolimus ointment could cause skin irritations, such as redness, stinging, burning, and itching. If large amounts of the ointment are taken by mouth, overdose symptoms also could occur.

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What should be careful while taking Tacrolimus?

Tacrolimus is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis, severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, and the skin condition vitiligo.

Tacrolimus(CAS NO: 104987-11-3) is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production by T-cells.

What is Tacrolimus used for?

Short-term treatment of moderate to severe atopic dermatitis in certain patients.Tacrolimus ointment is a topical immunosuppressant. How it works is not completely understood. It is thought to decrease the cell activity that causes atopic dermatitis.

Do NOT use tacrolimus if you have fellowing Symptoms:

You are allergic to any ingredient in tacrolimus ointment.
You are receiving any form of light therapy (eg, ultraviolet light therapy) on your skin.
You have a skin infection (eg, chickenpox, herpes, shingles) at the application site, certain skin problems (eg, a precancerous skin condition, skin cancer, Netherton syndrome), or a weakened immune system

What are the possible side effects of tacrolimus?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as: fever, chills, body aches, flu symptoms, sores in your mouth and throat; pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; pain in the lower back or side, blood in your urine, pain or burning when you urinate; urinating less than usual or not at all; dry cough.

What are the precautions when taking tacrolimus (Prograf)?

Before taking tacrolimus, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications (e.g., sirolimus, erythromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using Tacrolimus, tell your doctor or pharmacist your medical history, especially of: mineral imbalances (e.g., high potassium), kidney disease, any recent/current infections, cancer, liver disease, high blood pressure, diabetes.

Tacrolimus may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms.

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