Something important about Tetrakis(triphenylphosphine)palladium

Tetrakis(triphenylphosphine)palladium is one kind of yellow powder. The the IUPAC name of this chemical is palladium; triphenylphosphane. Besides, Tetrakis(triphenylphosphine)palladium belongs to straight chain compounds; Metal Compounds; blocks; pharmacetical; Catalysts-Ligands; Catalysts for Organic Synthesis; Classes of Metal Compounds; Homogeneous Catalysts; Metal Complexes; Pd (Palladium) Compounds; Synthetic Organic Chemistry; Transition Metal Compounds; Fine Chemical Catalysts; metal-phosphine complexes. 

In addition, Tetrakis(triphenylphosphine)palladium is insoluble in water. The compound is sensitive to air, but can be purified by washing with methanol to give the desired yellow powder.  The CAS NO is 14221-01-3. It is usually stored cold under argon.

The structure and properties: 

The four phosphorus atoms are at the corners of a tetrahedron surrounding the palladium(0) center. This structure is typical for four-coordinate 18e complexes. The corresponding complexes Ni(PPh3)4 and Pt(PPh3)4 are also well known. Such complexes reversibly dissociate PPh3 ligands in solution, so reactions attributed to Pd(PPh3)4 often in fact arise from Pd(PPh3)3 or even Pd(PPh3)2.

The mainly usages:

Tetrakis (triphenylphosphine) palladium is widely used as a catalyst for palladium-catalyzed coupling reactions. Prominent applications include the Heck reaction, Suzuki coupling, Stille coupling, Sonogashira coupling, and Negishi coupling. These processes begin with two successive ligand dissociations followed by the oxidative addition of an aryl halide to the Pd center:
Pd(PPh3)4 + ArBr → PdBr(Ar)(PPh3)2 + 2 PPh3

Material Safety Data Sheet (MSDS):

Ingestion: If victim is conscious and alert, give 2-4 cupfuls, milk or water. Do not give anything to eat, a person in a coma. Get medical attention immediately.
Inhalation: Get medical attention immediately. Immediately from the scene to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin: Get medical attention immediately. At least 15 minutes, but with plenty of soap and water to wash the skin, remove contaminated clothing and shoes.
Eyes: Flush with plenty of water for at least 15 minutes, rinse eyes, occasionally lifting the upper and lower eyelids. Get medical attention immediately.

Handling and storage:

Storage: Store Tetrakis(triphenylphosphine)palladium in a refrigerator (about 4 degree). Keep container tightly closed. Protected storage of light and air. Stored under argon. Store in a cool, dry place, away from incompatible substances.

Treatment: Wash thoroughly after handling Tetrakis(triphenylphosphine)palladium. Only in well-ventilated places. Minimize dust generation and accumulation. Avoid contact with eyes, skin and clothing. Avoid ingestion and inhalation. Stored protected from light. Stored protected from air. Under argon use and storage.


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Hazards Identification of Tetrakis(triphenylphosphine)palladium

Potential Health Effects

Eye: Tetrakis(triphenylphosphine)palladium may cause eye irritation. 
Skin: May cause skin irritation. 
Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. 
Inhalation:Tetrakis(triphenylphosphine)palladium may cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. 
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. 
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. 
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

General Information: Use proper personal protective equipment.
Spills/Leaks: Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Handling and Storage

Handling: Wash thoroughly after handling Tetrakis(triphenylphosphine)palladium. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid Tetrakis(triphenylphosphine)palladium ingestion and inhalation. 
Storage: Keep refrigerated. (Store below 4ƒC/39ƒF.) Keep containers tightly closed. Store protected from light and air. Store in a cool, dry area away from incompatible substances.

Engineering Controls:

Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. 
Skin: Wear appropriate protective gloves to prevent skin exposure. 
Clothing: Wear appropriate protective clothing to prevent skin exposure. 
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.