Olmesartan medoxomil is a white to light yellowish-white powder or crystalline powder with a molecular weight of 558.59. It is practically insoluble in water and sparingly soluble in methanol. Formula of Olmesartan medoxomil is C29H30N6O6,CAS number is 144689-63-4 .
Olmesartan medoxomil is a prodrug that is rapidly hydrolyzed into olmesartan in the gastrointestinal tract. Olmesartan is rapidly absorbed from the gastrointestinal tract into the body, with a maximum plasma concentration of 0.22-2.1 mg/L and time to Cmax of 1.4-2.8 h following administration of olmesartan medoxomil 10-160 mg (Schwocho and Masonson 2001). For the same doses, the mean area under the concentration-time curve (AUC) was 1.6-19.9 mgh/L.
Olmesartan medoxomil(CAS NO:144689-63-4) should be used with caution in renal artery stenosis. Monitoring of plasma-potassium concentration is advised, particularly in the elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.
It should also be used with caution in aortic or mitral valve stenosis and in hypertrophic cardiomyopathy. Those with primary aldosteronism, and Afro-Caribbean patients (particularly those with left ventricular hypertrophy), may not benefit from an Olmesartan medoxomil.
There are some side effects of Olmesartan medoxomil we should take care of.
Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, slow/irregular heartbeat, unusual decrease in the amount of urine.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
Olmesartan medoxomil has been evaluated for safety in more than 3825 patients/subjects, including more than 3275 patients treated for hypertension in controlled trials. This experience included about 900 patients treated for at least 6 months and more than 525 for at least 1 year. Treatment with Olmesartan medoxomil was well tolerated, with an incidence of adverse reactions similar to placebo. Events generally were mild, transient and had no relationship to the dose of Olmesartan medoxomil.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. Want to learn more information about Olmesartan medoxomil, you can access the guidechem.com.
Methyl disulfide(DMDS) is of Slightly yellow transparent liquid, there is stench flavor, melting point is at -98 DEG C, boiling point 109. 5DEG C, insoluble in water, easily soluble in acetic acid, ethanol. The molecular formula is C2H6S2, molecular weight is 94.2, and the CAS NO is 624-92-0.
Dimethyl disulfide along with dimethyl sulfide and dimethyl trisulfide have been confirmed as volatile compounds given off by the fly-attracting plant known as dead-horse arum. These flies are attracted to the odor of fetid meat, they help pollinate this plant.
Methyl disulfide(CAS NO:624-92-0) is a stable pale yellow liquid which works as an effective product in the sulfiding process because of its high sulphur content. Methyl disulfide is used as activator of hydrogen desulfurization and precuring process in refining petroleum refining; it may used as cracking, coking inhibitor in petrochemical; it also used as solvent and pesticide intermediate
Despite its use in a wide variety of industrially important thermochemical processes, little is known about the thermal decomposition mechanism of dimethyl disulfide (DMDS). To obtain more insight, the radical decomposition mechanism of Methyl disulfide is studied theoretically and a kinetic model is developed accounting for the formation of all the decomposition products observed in the experimental studies available in literature.
Thermochemical data and rate coefficients are obtained using the high-level CBS-QB3 composite method. Among five methods tested (BMK/6-311G(2d,d,p), MPW1PW91/6-311G(2d,d,p), G3, G3B3, and CBS-QB3), the CBS-QB3 method was found to reproduce most accurately the experimental standard enthalpies of formation for a set of 17 small organosulfur compounds and the bond dissociation energies for a set of 10 sulfur bonds.
Enthalpies of formation were predicted within 4 kJ mol−1 while the mean absolute deviation on the bond dissociation enthalpies amounts to 7 kJ mol−1. From the theoretical study, a new reaction path is identified for the formation of carbon disulfide via dithiirane (CH2S2).
A reaction mechanism was constructed containing 36 reactions among 25 species accounting for the formation of all the decomposition products reported in literature. High-pressure limit rate coefficients for the 36 reactions in the reaction mechanism are presented. The kinetic model is able to grasp the experimental observations.
With the recombination of thiyl radicals treated as being in the low-pressure limit, the experimentally reported first-order rate coefficients for the decomposition of Methyl disulfide are reproduced within 1 order of magnitude, while the observed product selectivities of most compounds are reproduced satisfactory. Simulations indicate that at high conversions most of the carbon disulfide forms according to the newly identified reaction path involving the formation of dithiirane.
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Paclobutrazol is a plant growth regulator belonging to the triazole chemical class (U.S. EPA, 2007B). Paclobutrazol was first registered by U.S. EPA in 1985. At the time of preparation of this review in 2011, PBZ was undergoing registration review by U.S. EPA to determine whether it continues to meet the FIFRA standard for registration . As part of the registration review process, a summary document was issued. This document includes a factsheet describing the Environmental Fate of Paclobutrazol.
Paclobutrazol(CAS NO:76738-62-0) has been characterized as a compound with a moderate potential for mobility in soil and water environments. The summary document for registration review prepared by U.S. EPA documents that laboratory batch equilibrium studies indicated that this chemical has the capacity to be mobile under certain conditions. Studies with nine US soils ranging in texture from sand to silt loam indicated values for the soil adsorption coefficient KD in the range from 1.3 to 23.0 ml/g.
Adsorption appeared to increase with an increase in soil organic matter content and a decrease in soil pH. In the draft assessment report prepared by the United Kingdom adsorption data for 13 soils are summarized that show KD values in the range of 0.8-21.3 ml/g with a geometric mean of 4.3 ml/g. The ketone metabolite showed on average a slightly higher affinity for adsorption to soil with KD values in the range of 2.1-13.5 with a mean of 8.0 across 6 soils.
Results from laboratory soil column leaching experiments summarized in U.S. EPA indicated low mobility in the experiments using methine-labeled Paclobutrazol(CAS NO:76738-62-0) in soils ranging in texture from sand to clay-loam. The experiments using triazole-labeled Paclobutrazol showed low mobility in columns of sand and sandy loam soils, and mobility in loamy sand and clay loam soils. In all cases, the majority (58.6-90.7%) of applied Paclobutrazol aged residue did not leach out of the upper 10 cm of the treated soil columns.
Although characterized as moderately mobile in laboratory studies, no significant movement of this chemical was detected in field studies in agricultural soils. In the orchard studies, Paclobutrazol residues (parent plus degradate) were detected at 10% or less of total applied in soils with depths of 48 inches in the California study, 24 inches in West Virginia study, and 48 inches in the Florida study.
These depths are the maximum depths sampled at each study. No information was provided on the nature or type of soils in the summary document. The Paclobutrazol ketone metabolite was predominately detected in the subsurface soil layers, also at insignificant levels.
A scientific publication by Baris et al. (2010) provided information regarding the potential of Paclobutrazol to impact groundwater from its use on turf areas. Paclobutrazol was included in a comprehensive evaluation of water quality monitoring data and assessment. This evaluation considered water quality data for a large number of turf-related pesticides from 44 studies involving 80 golf courses in the US over a 20-year period. PBZ was found in 3/440 groundwater samples, with the highest detection at 4.2 µg/L.
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Mancozeb is non-systemic fungicide, Organic-Dithiocarbamate group. Foliar protection of many fruits, vegetables, nuts and field crops against a wide spectrum of fungal diseases including potato blight, leaf spots, scab on apples and pears, anthracnose and rust.
For seed treatment of rice, cotton, potatoes,safflower, sorghum, peanuts, tomatoes, flax, and cereal grains.Mancozeb(CAS NO:8018-01-7) does not induce in fungi and is therefore an essential componentof alternating spray program or of mixed formulations with systemic and other fungicides.
Polyvalence: use on more than 70 crops for the control of 400 fungal diseases of which mildews, excoriosis, black-rot, red fire, alternaria, etc. Multi-site action: making it an ideal partner for recent mono-site molecules.
Nutrient: correction of crop deficiencies in manganese and zinc.The worldwide use mancozeb(CAS NO:8018-01-7) without danger to the environment. Because mancozeb break down rapidly in the environment. It is not harmful to beneficial insects and natural pollinators. Hence it is a useful product in integrated pest management programs. Mancozeb is a contact fungicide which remains on the treated surface of the plant.
Mancozeb is a member of the ethylene bisdithiocarbamate (EBDC) group of fungicides that also includes the related active ingredient metiram, the only other registered EBDC. A third EBDC, maneb, is no longer registered for use.
Mancozeb and metiram are metabolized to ethylenethiourea (ETU) in the body and both degrade to ETU in the environment. Therefore, EPA has considered the aggregate or combined risks from food, water and non-occupational exposure resulting from mancozeb alone and ETU from all sources (i.e., the other EBDC fungicides) for this action. EPA's assessment of exposures and risks associated with mancozeb and ETU follows.
Mancozeb is not acutely toxic via the oral, dermal or inhalation routes of exposure. Further, mancozeb is not a skin irritant nor is it a skin sensitizer, although it does cause mild eye irritation. The findings in multiple studies demonstrate that the thyroid is a target organ for mancozeb.
Thyroid toxicity is manifested as alternations in thyroid hormones, increased thyroid weight, and microscopic thyroid lesions (mainly thyroid follicular cell hyperplasia). These effects are due to the ETU metabolite.
Mancozeb is rapidly absorbed and eliminated in the urine. In oral rat metabolism studies with radiolabeled mancozeb and other EBDCs, an average 7.5%in vivo metabolic conversion of EBDC to ETU occurred, on a weight-to-weight basis.
Metabolism data indicate mancozeb does not bio-accumulate. Mancozeb has been tested in a series of in vitro and in vivo genotoxicity assays, which have shown that it exhibits weak genotoxic potential.
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Methyl acetoacetate is a kind of colorless liquid, we also call it Acetoacetic acid methyl ester or Butanoic acid, 3-oxo-, methyl ester. The Molecular Formula is C5H8O3, Molecular Weight is 116.12, and CAS Registry Number is 105-45-3.
Methyl acetoacetate is stable under normal temperatures and pressures. We should store Methyl acetoacetate in a cool, dry place, and keep the container closed when not in use. Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.
After introducting the basic properties of Methyl acetoacetate(CAS NO:105-45-3), I will show you some suppliers information about this chemical on Guidechem. If you need to buy this chemical, you can access to Guidechem, and contact them, I hope this information is useful for you.
Company one : Shanghai Dell Chemical Co.Ltd
Updatetime:Dec 10 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
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Address:Nianjiabang Rd, Pudong, Shanghai
Company two :Jinan Haohua Industry Co., Ltd.
Updatetime:Dec 10 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Acetoaceticacid, methyl ester (6CI,8CI); 3-Oxobutanoic acid methyl ester; 3-Oxobutyricacid methyl ester; Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl3-oxobutyrate; Methyl acetoacetate; Methyl acetylacetate
Tel:0086-531-58773055
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Company three : Nanjing Chemlin Chemical Co., Ltd.
Updatetime:Dec 09 2013
Purity:97.00%
DetailDesc:intermediates, drug discovery
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Company four : Finetech Industry Limited
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Updatetime:Oct 06 2013
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Company five : Conier Chem & Pharma Co.,Ltd.
Methyl acetoacetate
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Introduction: Conier Chem & Pharma Co.,Ltd. offers Pharmaceutical Intermediates, Fine Chemicals and APIs. We supply darifenacin, venlafaxine HCl, nebivolol, qQuetiapine, methoxyindole, 2-Methyl-5-pyrimidinemethanol and 4-phenoxypyridine. We develop comprehensive service in the field of chemical and pharmaceutical.
Company six : Goly Chemical Co., Ltd.
Methyl acetoacetate
Updatetime:Jan 16 2013
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Introduction:Goly Chemical Co., Ltd. specializes in Active Pharmaceutical Ingredients, Intermediates, Specialty Chemicals, and Water Treatment Agents & Food Additives. We focus on the Special Chemicals and Fine Chemicals such as Active Pharmaceutical Ingredients Organic Intermediates Inorganic Compound Amino Acid Series Fluoro-Compound.
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2-Bromo-3-hydroxypyridine, its systematic name is 2-bromopyridin-3-ol. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from light. It is used in organic synthesis.It can be used to produce 2-bromo-3-isopropoxypyridine at the temperature of 80 C. It will need reagent K2CO3 and solvent dimethylformamide with the reaction time of 2 hours.
1.Summary of the Hazards
When you are using 2-Bromo-3-hydroxypyridine(CAS NO:6602-32-0), please be cautious about it as the following: 2-Bromo-3-hydroxypyridine is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin; in case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice, when using it, you need wear suitable protective clothing and must avoid contact with eyes.
2.First Aid Measures
Eyes:
Check for and remove any contact lenses. IMMEDIATELY flush eyes with runing water for at least 15 minutes; Keeping eyelids open. COLD water may be used; DO NOT use an eye oitment. Flush eyes with running water for a minimum of 15 minutes, occasionally lifting the upper eyelids. Seek medical attention. Treat symptomatically and supportively.
Skin:
If 2-Bromo-3-hydroxypyridine(CAS NO:6602-32-0) contact with skin, wash immediately with plenty of water. Gently and thorough wash the contaminated skin with running water and non-abrasive soap; Be particularly careful to clean folds, crevices, creases and groin; COLD water may be used; Cover the irritated skin with an emollient. Seek medical attention. Treat symptomatically and supportively. Wash any contaminated clothing before reusing.
Inhalation:
If the victim is not breathing, perform artificial respiration. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, oxygen can be administered; Seek medical attention. Treat symptomatically and supportively.
Ingestion:
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat; Loosen tight clothing such as a collar, tie, belt, or waistband. If the victim is not breathing, administer artificial respiration. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Seek immediate medical attention and, if possible, show the chemical label. Treat symptomatically and supportively.
3.Accidental Release Measures
In case of a spill or a leak, always shut off any sources of ignition, ventilate the area, and exercise caution. Use a shovel to put the material into a convenient waste disposal container; Finish cleaning the spill by rinsing anycontaminated surfaces with copious amounts of water; Consult federal, state, and/or local authorities for assistance on disposal.
4.Handling and Storage
Keep 2-Bromo-3-hydroxypyridine away from heat and sources of ignition. Mechanical exhaust required; When 2-Bromo-3-hydroxypyridine is not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe 2-Bromo-3-hydroxypyridine dust; Always store 2-Bromo-3-hydroxypyridine away from incompatible compounds such as oxidizing agents.
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Indazole-3-carboxylic acid is used in organic synthesis. For example: it can react with 1,4-dimethyl-[1,4]diazepan-6-ylamine to get 1H-indazole-3-carboxylic acid.This reaction needs reagent 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride and solvent CH2Cl2 at ambient temperature. The reaction time is 5 hours. The yield is 21%.
When you are using Indazole-3-carboxylic acid(CAS NO:4498-67-3), please be cautious about it as the following: Indazole-3-carboxylic acid is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. So people should not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact Indazole-3-carboxylic acid, you must wear suitable protective clothing, gloves and eye/face protection.
Potential Health Effects about Indazole-3-carboxylic acid(CAS NO:4498-67-3)
Eye: Causes eye irritation.
Skin: Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled.
Chronic: No information found.
First Aid Measures about Indazole-3-carboxylic acid
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing
Skin: contaminated clothing and shoes.
Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center.
Inhalation:Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.
Fire Fighting Measures about Indazole-3-carboxylic acid
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling and Storage about Indazole-3-carboxylic acid
Handling: Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Storage: Store in a cool, dry place. Store in a tightly closed container.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure to Indazole-3-carboxylic acid.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators:Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
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