Chemical and physical properties:
Product Name: 6-Hydroxynicotinic Acid
English Synonyms:
2-Hydroxy-5-pyridinecarboxylic acid
CAS No.: 5006-66-6
Molecular formula: C6H5NO3
Molecular Weight: 139.11
Appearance Description: 6-Hydroxynicotinic
acid is a kind of white to brown powder.
The usages of 6-Hydroxynicotinicacid:
6-Hydroxynicotinic acid is an important
chemical intermediate, which can produce a number of important drugs and
pesticides. In the latest development of chemical pesticides, the
nitrogen-containing heterocyclic compounds like pesticides in pesticide occupy
a major position to imidacloprid, Acetamiprid represented pyridylmethylamine
pesticides with high efficiency, broad-spectrum, low toxicity characteristics ,
is the focus of today's development of new pesticides, while the six - hydroxy
acid is a important intermediate to synthetic pesticide pyridylmethylamine.
6-Hydroxynicotinic acid is also widely used
in medicine and dyes, synthetic materials, for example, uses 6-Hydroxynicotinic
acid and chlorine reaction of 5,6 - dichloro-nicotinic acid, is a way to
prevent the body's absorption of fat and promote the degradation of fat lipase
substances can be used as a weight loss drug. In the materials field and
6-Hydroxynicotinic acid can react with silicon produces a luminescent material.
Production method:
At present, 6-Hydroxynicotinic acid
production is mainly rely on chemical method, but many by-products, and are
difficult to separate, resulting in high production costs. Abroad from the
1980s onwards, the advanced biological catalysis niacin production of
6-Hydroxynicotinic acid conducted applied research, technology is more mature,
but foreign imports 6-Hydroxynicotinic acid prices are also very expensive.
There is a common industrial biocatalytic
production of 6-Hydroxynicotinic acid (i.e. a general method biotransformation
cell culture / resting cells transformed step transformation method is the use
of a fermentation broth containing substrate induced culture cells, and
products of the fermentation process may be degraded cells, therefore, can only
be obtained during the fermentation induction culture cells, and the obtained
transformed cells for resting cells, access to the product).
Biological production control
Biological production of 6-Hydroxynicotinic acid
process does not use toxic reagents and flammable organic solvents, green
production process safety and environmental protection. Each production cycle
of 6 to 7 tons waste, including three tons fermentation wastewater contains a
concentration of nutrients in the fermentation residues, and another 3 to 4
tons catalysis and product separation of wastewater containing a small amount
of residual 6-Hydroxynicotinic acid and acid-base neutralized NaCl. Wastewater
generated can be easily reached by conventional sewage treatment discharge
standards and inexpensive. It will not cause environmental pollution. Solid
waste is mainly abandoned cell, free of heavy metals and other toxic substances
that can direct incineration and landfill.
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