Resveratrol in red wine

British scientists behind the study concluded that red wine has powerful antioxidant ability of resveratrol and quercetin can be used as an anti-inflammatory agent that new. However resveratrol from red wine is too expensive, scientists will compare the benefits of resveratrol with its valueo and essence, the effect is still skeptical.

The team from Imperial College London confirmed that resveratrol (CAS NO: 501-36-0) has extensive anti inflammation ability, they also found that resveratrol has potential application in chronic pulmonary obstruction (COPD), asthma and even the treatment of arthritis. But they emphasized clinically dispensing and administration ways remains a problem.

Resveratrol in red wine has long been considered relationship with the "French paradox", the so-called French paradox that the French eat high fat diet a lot, but the incidence of cardiovascular disease not along with the increase of dietary status, because eating is not the matched results therefore, known as the "paradox" or "contradiction". Grape skin and Mei Zi (plum) can extract the polyphenol compounds, although there is still considerable controversy about the student body activity of these antioxidants, the product is available in the market.

The Louise team has examined Donnelly resveratrol products commercially available, they find that it is not of high purity, taking value debatable. This compound bioavailability problems mainly come from the resveratrol which can only soluble in some solvents, such as alcohol, the liver can be rapidly metabolized.

But the research team Imperial Academy of Sciences indeed found that resveratrol promotes human tracheal epithelial release anti-inflammatory substances.

Results of the study published in the anti-inflammatory mediator, they also contain some reaction may transfer, such as estrogen and glucocorticoid receptors. This means that the preparation has the potential for inflammatory diseases, especially those with Glucocorticoid therapy of diseases, such as chronic obstructive pulmonary disease, steroid resistant asthma and arthritis.

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Lung nilfisk "resveratrol research project" obtains the United States Patent

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, the CAS NO is 501-36-0 and a phytoalexin produced naturally by several plants – especially the roots of the Japanese Knotweed, from which it is extracted commercially – when under attack by pathogens such as bacteria or fungi.

The effects of resveratrol are currently a topic of numerous animal and human studies. Its effects on the lifespan of many model organisms remain controversial, with uncertain effects in fruit flies, nematode worms, and short-lived fish. In mouse and rat experiments, anticancer, anti-inflammatory, blood sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported. In this article, we will talk about the use of resveratrol on Life extension.

Recently, a research by Tsinghua University, lung nilfisk combined, named "resveratrol phosphatide compound nanometer emulsion projects" obtained the authorization of the United States Patent and Trademark Office (Patent No. US008465757B2).

It is reported, the patent complex synthesis of resveratrol and phospholipid, forming a unique distribution, the distribution system to form an emulsion particle size of less than 200 nm through high-pressure homogenizer or micro jet homogenizer. The advantage of the nanoemulsion is miscible with water in any ratio, and has good stability and bioavailability. The technology has been used for its elegant bright Platinum Series anti-aging skin care products.

Resveratrol is a famous SIRT1 protein activator, it was found in grape wine on 1940 for the first time, it was also found to contain resveratrol, after a study confirmed it as the main components of red wine health effect. In medicine, health food field, resveratrol has been widely used in anticancer, prevention and treatment of cardiovascular disease and weight reduction. The United States of America "anti-aging" has columned it to 100 one of the most 100 effective anti-aging substances.

Resveratrol used in cosmetics, can regulate energy metabolism through the activation of SIRT1 protein, the level of oxygen free radical, improve the genome stability, prolong the cell and the organism's own life, so as to achieve anti-aging effects; resveratrol can down-regulate the expression of MCR1, decreased KIT, TYR, SLC45A2, MREG gene expression in a variety of signaling pathways inhibition of tyrosinase activity, blocking the formation and transport of melanin, brighten complexion. The performance and application of the College of life science, its joint Tsinghua University resveratrol were studied, the breakthrough to the application of nanometer lipid transfer technology, solves the resveratrol in water and lipid solubility of low, not easy to add into the formula and the skin transmission poor shortcomings, improve the solubility of resveratrol, transdermal absorption utilization rate and biological properties.

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Benefits and Side Effects of Resveratrol

Resveratrol is a member of a group of plant compounds called polyphenols. These compounds are thought to have antioxidant properties, protecting the body against the kind of damage linked to increased risk for conditions such as cancer and heart disease. Resveratrol is found in the skin of red grapes, but other sources include peanuts and berries.

Because resveratrol is thought to have so many health benefits, it's not surprising that a number of manufacturers have tried to capitalize by selling resveratrol supplements. Most resveratrol capsules sold in the U.S. contain extracts from the Japanese and Chinese knotweed plant Polygonum cuspidatum. Other resveratrol supplements are made from red wine or red grape extracts.

1. Benefits of Resveratrol

Resveratrol has gained a lot of attention for its reported antiaging and disease-combating benefits. Early research, mostly done in test tubes and in animals, suggests that resveratrol might help protect the body against a number of diseases, including:

(1)Heart disease: Resveratrol helps reduce inflammation, prevents the oxidation of LDL "bad" cholesterol, and makes it more difficult for platelets to stick together and form the clots that can lead to a heart attack.

(2)Cancer: Resveratrol is thought to limit the spread of cancer cells and trigger the process of cancer cell death (apoptosis).

(3)Alzheimer's disease: Resveratrol may protect nerve cells from damage and the buildup of plaque that can lead to Alzheimer's.

(4)Diabetes: Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the effects of the blood sugar-lowering hormone, insulin. Insulin resistance is a precursor to diabetes.

(5)Others: Rodent studies suggest that resveratrol might even help against some of the effects of an unhealthy lifestyle and lead to increased longevity. Resveratrol-treated mice fed a high-calorie diet lived longer than similarly fed mice not given resveratrol. Resveratrol protected mice fed a high-calorie diet from obesity-related health problems by mimicking the effects of caloric restriction.

Resveratrol has also been linked to prevention of age-related problems such as heart disease and insulin resistance. Researchers believe that resveratrol activates the SIRT1 gene, a biological mechanism that seems to protect the body against the harmful effects of obesity and the diseases of aging.

2. Side Effects

Because there have been very few studies conducted on resveratrol in humans, doctors still can't confirm any benefits, and they don't know what effects these supplements might have on people over the long term. So far, studies have not discovered any severe side effects, even when resveratrol is taken in large doses. However, resveratrol supplements might interact with blood thinners such as warfarin (Coumadin), and nonsteroidal anti-inflammatory medications such as aspirin and ibuprofen, increasing the risk for bleeding.

Like other supplements, resveratrol isn't regulated by the FDA, so it's difficult for consumers to know exactly what they're getting when they buy a bottle, or whether the product is actually effective. There also isn't any specific dosage recommendation, and dosages can vary from supplement to supplement.

The dosages in most resveratrol supplements are typically far lower than the amounts that have been shown beneficial in research studies. Most supplements contain 250 to 500 milligrams of resveratrol. To get the equivalent dose used in some animal studies, people would have to consume 2 grams of resveratrol (2,000 milligrams) or more a day.

Until more high-quality research is available, experts say they can't recommend resveratrol supplements for antiaging or disease prevention.

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