Resveratrol is a member of a group of plant
compounds called polyphenols. These compounds are thought to have antioxidant
properties, protecting the body against the kind of damage linked to increased
risk for conditions such as cancer and heart disease. Resveratrol is found in
the skin of red grapes, but other sources include peanuts and berries.
Because resveratrol is thought to have so
many health benefits, it's not surprising that a number of manufacturers have
tried to capitalize by selling resveratrol supplements. Most resveratrol
capsules sold in the U.S.
1. Benefits of Resveratrol
Resveratrol has gained a lot of attention
for its reported antiaging and disease-combating benefits. Early research,
mostly done in test tubes and in animals, suggests that resveratrol might help
protect the body against a number of diseases, including:
(1)Heart disease: Resveratrol helps reduce
inflammation, prevents the oxidation of LDL "bad" cholesterol, and
makes it more difficult for platelets to stick together and form the clots that
can lead to a heart attack.
(2)Cancer: Resveratrol is thought to limit
the spread of cancer cells and trigger the process of cancer cell death
(apoptosis).
(3)Alzheimer's disease: Resveratrol
may protect nerve cells from damage and the buildup of plaque that can lead to
Alzheimer's.
(4)Diabetes: Resveratrol helps prevent
insulin resistance, a condition in which the body becomes less sensitive to the
effects of the blood sugar-lowering hormone, insulin. Insulin resistance is a
precursor to diabetes.
(5)Others: Rodent studies suggest that
resveratrol might even help against some of the effects of an unhealthy
lifestyle and lead to increased longevity. Resveratrol-treated mice fed a
high-calorie diet lived longer than similarly fed mice not given resveratrol.
Resveratrol protected mice fed a high-calorie diet from obesity-related health
problems by mimicking the effects of caloric restriction.
Resveratrol has also been linked to
prevention of age-related problems such as heart disease and insulin
resistance. Researchers believe that resveratrol activates the SIRT1 gene, a
biological mechanism that seems to protect the body against the harmful effects
of obesity and the diseases of aging.
2. Side Effects
Because there have been very few studies
conducted on resveratrol in humans, doctors still can't confirm any benefits,
and they don't know what effects these supplements might have on people over
the long term. So far, studies have not discovered any severe side effects,
even when resveratrol is taken in large doses. However, resveratrol supplements
might interact with blood thinners such as warfarin (Coumadin), and
nonsteroidal anti-inflammatory medications such as aspirin and ibuprofen,
increasing the risk for bleeding.
Like other supplements, resveratrol isn't
regulated by the FDA, so it's difficult for consumers to know exactly what
they're getting when they buy a bottle, or whether the product is actually
effective. There also isn't any specific dosage recommendation, and dosages can
vary from supplement to supplement.
The dosages in most resveratrol supplements
are typically far lower than the amounts that have been shown beneficial in
research studies. Most supplements contain 250 to 500 milligrams of
resveratrol. To get the equivalent dose used in some animal studies, people
would have to consume 2 grams of resveratrol (2,000 milligrams) or more a day.
Until more high-quality research is
available, experts say they can't recommend resveratrol supplements for
antiaging or disease prevention.
Frankie is the freelance writer for
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