Gemcitabine hydrochloride is an anticancer drug

The name of the drug: Gemcitabine Hydrochloride for Injection

The main components of the drugs: This product mainly consists of gemcitabine hydrochloride.

Traits of Gemcitabine hydrochloride: This product is a white loose block.

CAS NO of Gemcitabine　Hydrochloride :  122111-03-9

Pharmacological action of Gemcitabine Hydrochloride: Gemcitabine hydrochloride is a nucleoside analogues, belongs to the cell cycle specific antitumor drugs. The main killer in S phase (DNA synthesis) cells, at the same time also blocked cell proliferation by G1 to S transition process. This product is superseded by intracellular nucleoside kinase metabolism into 2-nucleoside phosphate activity (dFdCDP) and 3- nucleotide (dFdCTP).

The cytotoxic activity was derived from the two kinds of nucleoside combined effect of DNA synthesis inhibition. Resulting DNA (including dCTP) reduced the concentration of gemcitabine, three phosphate can compete with dCTP binding to DNA, while the dCTP concentration in the cells decreased (generated by the role of phosphate) combined with gemcitabine can promote three phosphoric acid and DNA, the result of a nucleotide incorporation into the synthesis process DNA chain, so as to prevent further synthesis of DNA. In addition, DNA polymerase epsilon is not able to clear the gemcitabine nucleotides and repair synthesis process of the DNA chain.

Adaption of Gemcitabine Hydrochloride:  Suitable for the treatment of advanced non small cell lung cancer.

Usage and dosage of GemcitabineHydrochloride: Recommended adult dose of gemcitabine for 30 minutes 1000mg/m2 intravenous drip, once a week, for three weeks, then rest a week, each around again.

On the basis of toxicity reaction of patients decreased dose. Preparation method: bottle (including gemcitabine 200mg) at least 0.9% injection of sodium chloride injection 5ml (including the concentration of gemcitabine ≤ 40mg/ml), and shake to dissolve, when administered to the required quantity available in 0.9% sodium chloride injection further dilution, preparing gemcitabine solution good should be stored in room temperature and used within 24 hours, gemcitabine solution may not be refrigerated, to prevent crystallization.

Elderly patients: elderly patients aged 65 years and above can also very good tolerance. Despite the influence of age clearance and half-life of gemcitabine, but there is no evidence that elderly patients require dose adjustment. Children: not studied the use of gemcitabine in children.

Medication for pregnant and lactation: The B3 class, the drugs on the safety of pregnant women is unknown. The animal experiment showed that, the drug has reproductive toxicity, such as reproductive defects or the development of the embryo and fetus, before and after pregnancy and childbirth and other toxic effect. Gemcitabine has potential risk to the fetus and infant, therefore, pregnant and lactating women should avoid the use it.

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