What should be careful about Tacrolimus overdose

Tacrolimus lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader. 

Tacrolimus is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant. It may also be used for purposes not listed in this medication guide. But it is possible for someone to use too much tacrolimus(CAS NO:104987-11-3). The overdose effects will vary, based on certain factors. Possible symptoms include hives, tremors, and kidney problems. Treatment will typically involve supportive care to treat any symptoms that occur as a result of the overdose, in addition to pumping the stomach.

Treatment for a Tacrolimus Overdose

The treatment for an overdose of tacrolimus may vary. If the overdose was recent and taken by mouth, a healthcare provider may "pump the stomach" to help reduce the amount of the drug absorbed into the bloodstream. Dialysis is not expected to be helpful for removing tacrolimus from the bloodstream.

Treatment will also include supportive care, which consists of treating the symptoms that occur as a result of the overdose. For example, supportive treatment for a tacrolimus overdose may include:

Fluids through an intravenous line (IV), if necessary
Close monitoring of kidney function, body salts (electrolytes), and blood pressure
Medications to treat high blood pressure, if needed.

It is important that you seek medical attention immediately if you believe that you or someone else may have overdosed on this medication.

Effects of an Overdose

There have been reports of overdoses of up to 30 times the recommended tacrolimus dose. Based on these cases, possible overdose symptoms may include but are not limited to:
Tremors
Kidney problems
High blood pressure (hypertension)
Swelling (edema) of the arms, hands, legs, ankles, or feet
Hives
Loss of energy.

These symptoms are unlikely to occur from a tacrolimus ointment overdose, however, as very little of the medicine is absorbed through the skin into the bloodstream. Using too much tacrolimus ointment could cause skin irritations, such as redness, stinging, burning, and itching. If large amounts of the ointment are taken by mouth, overdose symptoms also could occur.

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