MSDS of Indazole-3-carboxylic acid

Indazole-3-carboxylic acid is used in organic synthesis. For example: it can react with 1,4-dimethyl-[1,4]diazepan-6-ylamine to get 1H-indazole-3-carboxylic acid.This reaction needs reagent 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride and solvent CH2Cl2 at ambient temperature. The reaction time is 5 hours. The yield is 21%.

When you are using Indazole-3-carboxylic acid(CAS NO:4498-67-3), please be cautious about it as the following: Indazole-3-carboxylic acid is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. So people should not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact Indazole-3-carboxylic acid, you must wear suitable protective clothing, gloves and eye/face protection.

Potential Health Effects about Indazole-3-carboxylic acid(CAS NO:4498-67-3)

Eye: Causes eye irritation. 
Skin: Causes skin irritation. May be harmful if absorbed through the skin. 
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. 
Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. 
Chronic: No information found. 

First Aid Measures about Indazole-3-carboxylic acid

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.  Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing   
Skin: contaminated clothing and shoes. 
Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center. 
Inhalation:Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. 
Notes to Physician: Treat symptomatically and supportively. 

Fire Fighting Measures about Indazole-3-carboxylic acid

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. 
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 


Handling and Storage about Indazole-3-carboxylic acid

Handling: Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. 
Storage: Store in a cool, dry place. Store in a tightly closed container.

Personal Protective Equipment 

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. 
Skin: Wear appropriate protective gloves to prevent skin exposure to Indazole-3-carboxylic acid. 
Clothing: Wear appropriate protective clothing to prevent skin exposure. 
Respirators:Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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