What you know about Calcitonin salmon?

Calcitonin salmon Injection, Synthetic is indicated for the treatment of symptomatic Paget's disease of bone, for the treatment of hypercalcemia, and for the treatment of postmenopausal osteoporosis.

Calcitonin salmon(CAS NO: 47931-85-1) is used to treat osteoporosis in women who are at least 5 years past menopause and cannot or do not want to take estrogen products. Osteoporosis is a disease that causes bones to weaken and break more easily. Calcitonin is a human hormone that is also found in salmon. It works by preventing bone breakdown and increasing bone density .

Some medical conditions may interact with Calcitonin salmon(CAS NO: 47931-85-1) spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances.

The hormone participates in calcium and phosphorus metabolism. In many ways, calcitonin counteracts parathyroid hormone .More specifically, calcitonin lowers blood Ca2+ levels in three ways:Inhibits Ca2+ absorption by the intestines; Inhibits osteoclast activity in bones; Inhibits renal tubular cell reabsorption of Ca2+ allowing it to be excreted in the urine.

However, effects of calcitonin that mirror those of PTH include the following:
Inhibits phosphate reabsorption by the kidney tubules.
In its skeleton-preserving actions, calcitonin protects against calcium loss from skeleton during periods of calcium mobilization, such as pregnancy and, especially, lactation.
Other effects are in preventing postprandial hypercalcemia resulting from absorption of Ca2+. Also, calcitonin inhibits food intake in rats and monkeys, and may have CNS action involving the regulation of feeding and appetite.

The panel voted 12-9 that the benefit of calcitonin salmon products in treating bone-thinning associated with osteoporosis is outweighed by a potential increase in the risk of cancer. It is a man-made version of the hormone calcitonin that is found in salmon. It products include Novartis AG's Miacalcin injection and nasal spray and Unigene Laboratories Inc's nasal spray. Privately held Upsher Smith Laboratories Inc distributes Unigene's product in the United States. Generic calcitonin products are also available.

The panel voted 20-1 that companies developing new calcitonin salmon products must prove they are effective in reducing fracture risk.The result follows an FDA staff review that found significant questions remain over whether calcitonin salmon is effective in reducing fractures.

Last July, European regulators recommended that long-term use of Calcitonin salmon be curtailed after a review found evidence of a small increased risk of cancer with long-term use of the drugs.They ruled that the benefits of Calcitonin salmon-containing medicines did not outweigh their risks in the treatment of osteoporosis and that they should no longer be used for this condition.

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