2013年9月2日星期一

Hypericin from Hypericin perforatum

Product name: Hypericin
Latin names: Hypericin perforatum L.
CAS NO: 548-04-9
EINECS: 208-941-0
Formula: C30H16O8
Molecular Weight: 504.45

Hypericin is derived from perforatum of the whole plant extract, the main ingredients of Hypericin extract is hypericin, faint scent. Hypericin has bitter taste, soluble in water. It has antidepressant, anti-viral effect. Hypericin is also used as veterinary drugs for prevention of avian influenza in chickens.

Hypericin is a kind of brown flowing powder, smells the unique fragrance, bitter taste, soluble in water. Hypericin may be blue-black or purple needle crystal. It is easily soluble in pyridine and other organic bases, a cherry red solution and was red fluorescence. The aqueous alkali solution of Hypericin is almost insoluble in other organic solvents. In pH11.5 less is red, pH11.5 above is green, and shows a red fluorescence. Melting point> 320 (decomposition).

According to the report of the British Medical Journal study in 2000, comparing Hypericin with imipramine, the efficacy of the treatment of depression are both similar, but more acceptable to patients taking Hypericin, which 26% of the patients have adverse reactions after taking imipramine, give up taking the drug. But for Hypericin group, only 3% of patients give up taking it. Hypericin is herbs that many people have studied, clinical experience, and drug generally safe.

By the Chinese Academy of Agricultural Sciences, Lanzhou Institute of Animal Husbandry and Veterinary submitted to the National Avian Influenza Reference Laboratory "hypericin and the H9N2 avian influenza virus subtype H5N1 killing effect" test completed. The results showed that hypericin on highly pathogenic avian influenza virus killing effect is good, and finally kill rate of up to 100%.

Chinese Academy of Agricultural Sciences, Lanzhou Institute of Animal Husbandry and Veterinary, Ministry of Agriculture Key Laboratory director Liang Jianping said, inspection reports indicate that at different concentrations, respectively, and the hypericin and the H9N2 avian influenza virus subtype H5N1 in vitro direct contact, wherein the hypericin containing 3.72mg per ml concentration of crude drugs, the avian influenza virus for 30 minutes, the virus up to 100% kill rate in 0.744mg of crude drug per ml concentration range, and avian influenza virus for 10 minutes, the virus kill rate of up to 99.99%.



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