What is Zonisamide used for?

Zonisamide (zoh-NIH-sah-mide) is the generic name (non-brand name) used in the United States for a widely used seizure medicine. The common brand name for Zonisamide is Zonegran (ZAHN-uh-gran).Zonisamide is marketed in the United States by several manufacturers. The name or appearance may differ in other places.

Zonisamide(CAS NO.:68291-97-4) is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.

It can be used for preventing children seizures,It is important that your child takes this medicine regularly so that they have fewer seizures.Do not stop giving it suddenly, as your child may have more seizures.

You will usually start by giving this medicine once a day, while your child gets used to the medicine. This is usually in the evening. When your child is used to zonisamide, you will usually give it twice a day: once in the morning and once in the evening. Ideally, these times are 10–12 hours apart, for example sometime between 7 and 8 am and between 7 and 8 pm.

Zonisamide should not be given with food, as it will not work properly. Your child can have food half an hour after taking the medicine.Capsules should be swallowed whole with a glass of water, or juice. Your child should not chew the tablets.To help give the medicine, you can open the capsule and sprinkle the contents into a teaspoonful of soft food such as yogurt, honey or jam. Make sure your child swallows it all straight away, without chewing. Your child should not eat any more food for at least half an hour.

Zonisamide is an anticonvulsant medication that is unrelated to other anticonvulsants routinely used in dogs and cats. For dogs that cannot tolerate Phenobarbital or potassium bromide, zonisamide may be a viable option. It may also be an option for dog owners who do not want to risk the side effects of phenobarbital or potassium bromide for their dog. While zonisamide appears to be effective in controlling seizures for many dogs and seems to be well-tolerated, many veterinarians are still concerned that we not know the entire range of side effects possible with the drug because its use has been somewhat limited so far.

Zonisamide is still somewhat controversial as a medication to control seizures in cats as well. However, some veterinarians have used it successfully. Zonisamide levels in the blood can be measured but there is a lack of agreement between veterinarians regarding whether measurement of blood levels is needed. Some veterinarians believe that measuring is important to evaluate whether the dosage is adequate and is not approaching toxic levels. Others prefer to rely on clinical signs and monitoring of seizure activity to determine the efficacy of the medication dosage for the pet.

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