The usages of Aloe-emodin

The antimicrobial active ingredient of rhubarb is Aloe-emodin. Aloe-emodin is an orange yellow needle crystal or soil crystalline powder chemical, which can be extracted from the aloe vera, it has anti-tumor activity, antibacterial activity and immunosuppressive effects, diarrhea effect, is now widely used as a pharmaceutical, cosmetic raw materials.

This article we will talk about the different usages of Aloe-emodin.

Anti-tumor activity

In recent years, domestic and foreign scholars are quite interested in the anti-tumor effect of Aloe-emodin, mainly focused on the anti-tumor activity against neuroectodermal tumors, liver cancer, lung squamous cell carcinoma, Merkel cell skin cancer, stomach cancer, leukemia and other tumors, anticancer wide range of Aloe-emodin on P388 leukemia cells was inhibited, and prolong survival. One of its mechanism of action is the inhibition of cancer cell DNA, RNA and protein biosynthesis.

Antibacterial activity

In the 1.5 ~ 25mg/ml concentration, Aloe-emodin on staphylococcus, streptococcus, diphtheria bacillus, Bacillus subtilis, anthrax, paratyphoid, dysentery bacillus was inhibited, in which the most sensitive staphylococcus and streptococcus, antibacterial the effective concentration of 15-25ug/ml. Staphylococcus aureus 209P, Escherichia coli, Shigella flexneri in vitro inhibitory concentrations were 7.5mg / L, 600mg / L are bacteriostatic rather than its antibacterial sterilization. One of its mechanism of action is the inhibition of the mitochondrial respiratory chain electron transport. Aloe-emodin against Staphylococcus aureus nucleic acid and protein synthesis was strongly inhibited. Aloe-emodin against clinical anaerobic bacteria have a strong inhibitory effect, in which the common Bacteroides fragilis inhibited 90% to 100% of the isolates grow slightly above the MIC of metronidazole. In 8μg/ml concentration 76% to 91% anaerobic can be inhibited.

Immunosuppressive effects

Aloe-emodin can inhibit the organism antibody production, inhibition of carbon clearance ability to reduce the weight of immune organs, lower white blood cell count, decreased macrophage function. In 100μg/ml concentration on in vitro [3H]-TDR and [3H] Urd incorporation significantly inhibited lymphocyte.

The role of diarrhea

Aloe-emodin has strong purgative activity of intestinal bacteria metabolize aloe-emodin, rhein, rhein anthrone, which has a strong laxative effect. Clinically used as a laxative, appetite and large intestine with a laxative effect. According to foreign medical reports, aloin parasites in the human body is under the effect of hydrolysis of Aloe-emodin, aloe-emodin that stimulate intestinal peristalsis, and because changes in osmotic pressure, beneficial intestinal waste exclusion, so as to achieve irritating laxative, purgative effect of this stimulation for constipation and hemorrhoids with special effects. Especially for the elderly constipation, the treatment effect is more obvious.

Other functions

The role of lipid-lowering diet

Having to make hair soft and shiny, easy and comfortable, anti-dandruff effect

In hamster fibroblasts mutagenicity assays showed the product of genetic toxicity

It can protect against termite attack teak

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