Vinblastine sulfate for injection

Properties:

Vinblastine sulfate injection is a white or almost white loose-like or amorphous solid, hygroscopic, easy to turn yellow when exposed to light or heat.


Applicable symptoms:

Vinblastine sulfate injection is mainly used for the treatment of solid tumors. It also have a certain effect on malignant lymphoma, testicular cancer, choriocarcinoma good effect, lung cancer, breast cancer, ovarian cancer, skin cancer, Wilms' tumor and monocytic leukemia.


Notes:

Intravenous injection, into the vein to avoid direct sunlight, in the extravascular leakage must be timely treatment (reference nitrogen mustard leakage treatment), or local tissue necrosis can occur.


Dosage:

Adult dose of 10mg (or 6mg/m2), children's dose 10mg/m2, 1 week, a course of total 60 ~ 80mg.


Pharmacology:

Vinblastine sulfate was Apocynaceae Vinca plant extracts have anti-cancer activity of an alkaloid. Mainly inhibit tubulin polymerization, and prevent the formation of spindle microtubules, making stops at mid-mitosis. Can also act on the cell membrane, transport of amino acids interfere with the cell membrane, the inhibition of protein synthesis, also inhibit RNA synthesis. Vinblastine sulfate broad spectrum anti-tumor, at 0.05 ~ 0.1mg/kg dose L1210 leukemia in mice, Ehrlich ascites carcinoma, S180, C3H mice spontaneously and metastatic breast cancer have significant anti-tumor activity against transplanted in the hamster cheek pouch of velvet also inhibited the growth of cancer cells.


Adverse reactions:

1, hematologic toxicity: a dose-limiting toxicity, bone marrow suppression stronger than vincristine, rapid recovery after discontinuation.

2, gastrointestinal reactions: loss of appetite, nausea, vomiting, diarrhea, abdominal pain, stomatitis.

3, peripheral nerve toxicity: refers to (toe) tip numbness, pain in the limbs, muscle tremors, tendon reflexes disappeared.

4, local irritation: Injecting blood vessels can occur thrombophlebitis, in the extravascular leakage can cause local tissue necrosis.

5, Others: small number of patients orthostatic hypotension, hair loss, insomnia, headaches and so on.



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