Something important about Tetrakis(triphenylphosphine)palladium

Tetrakis(triphenylphosphine)palladium is one kind of yellow powder. The the IUPAC name of this chemical is palladium; triphenylphosphane. Besides, Tetrakis(triphenylphosphine)palladium belongs to straight chain compounds; Metal Compounds; blocks; pharmacetical; Catalysts-Ligands; Catalysts for Organic Synthesis; Classes of Metal Compounds; Homogeneous Catalysts; Metal Complexes; Pd (Palladium) Compounds; Synthetic Organic Chemistry; Transition Metal Compounds; Fine Chemical Catalysts; metal-phosphine complexes. 

In addition, Tetrakis(triphenylphosphine)palladium is insoluble in water. The compound is sensitive to air, but can be purified by washing with methanol to give the desired yellow powder.  The CAS NO is 14221-01-3. It is usually stored cold under argon.

The structure and properties: 

The four phosphorus atoms are at the corners of a tetrahedron surrounding the palladium(0) center. This structure is typical for four-coordinate 18e complexes. The corresponding complexes Ni(PPh3)4 and Pt(PPh3)4 are also well known. Such complexes reversibly dissociate PPh3 ligands in solution, so reactions attributed to Pd(PPh3)4 often in fact arise from Pd(PPh3)3 or even Pd(PPh3)2.

The mainly usages:

Tetrakis (triphenylphosphine) palladium is widely used as a catalyst for palladium-catalyzed coupling reactions. Prominent applications include the Heck reaction, Suzuki coupling, Stille coupling, Sonogashira coupling, and Negishi coupling. These processes begin with two successive ligand dissociations followed by the oxidative addition of an aryl halide to the Pd center:
Pd(PPh3)4 + ArBr → PdBr(Ar)(PPh3)2 + 2 PPh3

Material Safety Data Sheet (MSDS):

Ingestion: If victim is conscious and alert, give 2-4 cupfuls, milk or water. Do not give anything to eat, a person in a coma. Get medical attention immediately.
Inhalation: Get medical attention immediately. Immediately from the scene to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin: Get medical attention immediately. At least 15 minutes, but with plenty of soap and water to wash the skin, remove contaminated clothing and shoes.
Eyes: Flush with plenty of water for at least 15 minutes, rinse eyes, occasionally lifting the upper and lower eyelids. Get medical attention immediately.

Handling and storage:

Storage: Store Tetrakis(triphenylphosphine)palladium in a refrigerator (about 4 degree). Keep container tightly closed. Protected storage of light and air. Stored under argon. Store in a cool, dry place, away from incompatible substances.

Treatment: Wash thoroughly after handling Tetrakis(triphenylphosphine)palladium. Only in well-ventilated places. Minimize dust generation and accumulation. Avoid contact with eyes, skin and clothing. Avoid ingestion and inhalation. Stored protected from light. Stored protected from air. Under argon use and storage.


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