2013年10月23日星期三

You should learn more about D(-)-Salicin

White willow bark is the original source of D(-)-Salicin, a weaker forerunner of aspirin. Through the ages, long before the discovery of its constituent D(-)-Salicin, white willow bark was used to combat many painful conditions, including rheumatism, headache, neuralgia, arthritis, gout, and angina.

D(-)-Salicin (C13H18O7) is an alcoholic beta-glycoside which contains D-glucose. It is an anti-inflammatory which is produced from all willow barks.D(-)-Salicin(CAS NO.:138-52-3) is closely related chemically to aspirin and has a very similar action in the human body. 

When consumed, D(-)-Salicin is metabolized to salicylic acid. When ingested, D(-)-Salicin (the active glycoside in white willow) is converted into salicylic acid. (This compound has been synthesized into acetylsalicylic acid, otherwise known as aspirin.) Salicylic acid is believed to be the consitutent responsible for mediating white willows analgesic (pain relieving) effects. 

D(-)-Salicin may be used by some people that are limited to, or prefer, natural medicinal sources, as an anti-inflammatory, headache or pain relief, easing symptoms of arthritis, acne, psoriasis and warts. For reasons of safety, lower risk of side effects, and negative interaction with prescriptions such as gastrointestinal pain from ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs). We summary the main usages of D(-)-Salicin are in fellowing:
Analgesic (pain relieving) effect. 
Antiinflammatory and Control arthritis discomforts. 
Cosmetic Application. 
Antimicrobial activity against P. acnes makes it a good candidate for skin cleansing products. 
Herbal Aspirin.

D(-)-Salicin in small amounts is found in some foods, including berries, olives, mushrooms, nuts, almonds, seeds, raisins, tomatoes, radish, chicory, green pepper, alfalfa, broccoli, spinach, sweet potato, along with some spices such as curcuma, curry, turmeric, cumin, thyme, oregano, rosemary and mustard. Higher amounts are found in some herbs such as meadowsweet, wintergreen, especially wintergreen oil, poplar tree, sweet and white birch.

Salicylates aid in blood thinning, lowering production of two enzymes, prostaglandins and thromboxanes, which reduces inflammation and the potential of platelets to stick to one another, by acting as a natural oil cleanser to wipe up the sticky and greasy layer on platelet surfaces, lessening risk of blood clots, heart attacks and strokes. In addition, salicylates reduce additional tissue damage after coronary artery disease or heart attacks, as the blood thinner properties allow for better bloodflow through clogged arteries, while possibly reducing risk of cancer as angiogenesis of cancerous cells is associated with chronic inflammation.

Mild side effects are standard, with rare occurrences of nausea, vomiting, rash, dizziness and breathing problems. Overdose from high quantities of D(-)-Salicin can be toxic, damaging kidneys, stomach causing ulcers, diarrhea, bleeding or digestive discomfort. Some people may be allergic, or sensitive to salicylates, similar to reactions to aspirin. Others that are advised against taking D(-)-Salicin are those with asthma, diabetes, gout, gastritis, hemophilia, stomach ulcers, children under 16, pregnant and breastfeeding women.

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