What should be careful while taking Tacrolimus?

Tacrolimus is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis, severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, and the skin condition vitiligo.

Tacrolimus(CAS NO: 104987-11-3) is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production by T-cells.

What is Tacrolimus used for?

Short-term treatment of moderate to severe atopic dermatitis in certain patients.Tacrolimus ointment is a topical immunosuppressant. How it works is not completely understood. It is thought to decrease the cell activity that causes atopic dermatitis.

Do NOT use tacrolimus if you have fellowing Symptoms:

You are allergic to any ingredient in tacrolimus ointment.
You are receiving any form of light therapy (eg, ultraviolet light therapy) on your skin.
You have a skin infection (eg, chickenpox, herpes, shingles) at the application site, certain skin problems (eg, a precancerous skin condition, skin cancer, Netherton syndrome), or a weakened immune system

What are the possible side effects of tacrolimus?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as: fever, chills, body aches, flu symptoms, sores in your mouth and throat; pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; pain in the lower back or side, blood in your urine, pain or burning when you urinate; urinating less than usual or not at all; dry cough.

What are the precautions when taking tacrolimus (Prograf)?

Before taking tacrolimus, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications (e.g., sirolimus, erythromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using Tacrolimus, tell your doctor or pharmacist your medical history, especially of: mineral imbalances (e.g., high potassium), kidney disease, any recent/current infections, cancer, liver disease, high blood pressure, diabetes.

Tacrolimus may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms.

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