Study on the effects of (-)-Epigallocatechin gallat on Cancer

(-)-Epigallocatechin gallat is also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin, we also call it EGCG. It is stable, but may be light sensitive and incompatible with strong oxidizing agents. The Molecular Formula is C22H18O11, Molecular Weight is 458.37, and CAS Registry Number is 989-51-5.

It is the most abundant catechin in tea and is a potent antioxidant that may have therapeutic applications in the treatment of many disorders (e.g. cancer). It is found mainly in green tea and, in smaller quantities, black tea; during black tea production, the catechins are mostly converted to theaflavins and thearubigins, and theabrownins.

(-)-Epigallocatechin gallate (CAS NO:989-51-5) has been used for a tumor-inhibiting constituent of green tea for altering the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice. 

It has been the subject of a number of studies investigating its potential use as a therapeutic for a broad range of disorders: HIV, Cancer, Chronic fatigue syndrome, Sjögren's syndrome, Endometriosis, Spinal muscular atrophy, Neurodegeneration, Periapical lesions, Cannabinoid 1 receptor, CB1 receptor Activity.

(-)-Epigallocatechin gallat studies have shown that intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied. Reports have shown that green tea extract intake is associated with increased weight loss due to diet-induced thermogenesis, which is generally attributed to the catechin (-)-Epigallocatechin gallat. 

Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited. We determined the cancer chemopreventive potentials of 10 representative polyphenols and explored their structure-activity relationship. 

The effect of the 10 polyphenol compounds on the proliferation of HCT-116 and SW-480 human colorectal cancer cells was evaluated using an MTS assay. Cell cycle distribution and apoptotic effects were analyzed by flow cytometry after staining with propidium iodide (PI)/RNase or annexin V/PI. Among the 10 polyphenols, EGCG showed the most potent antiproliferative effects, and significantly induced cell cycle arrest in the G1 phase and cell apoptosis. 

When the relationship between chemical structure and anticancer activity was examined, C and EC did not show antiproliferative effects, and GA showed some antiproliferative effects. When C and EC esterified with GA to produce CG and ECG, the antiproliferative effects were increased significantly. 

A similar relationship was found between EGC and (-)-Epigallocatechin gallat. The (-)-Epigallocatechin gallat group significantly enhanced catechin's anticancer potential. This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents.

If you need take (-)-Epigallocatechin gallat, you should pay more attention to it. Learning more health information, properties or suppliers about (-)-Epigallocatechin gallat, you can access Guidechem.